Ultrasensitive Electrochemical Screening of Circulating Tumor Cells Over Single‐Atom Nanozyme Integrated 3D Nanoarray
Source abstract
Abstract
Abstract Late‐stage diagnosis is a major contributor to cancer mortality and thus leads to increased fatality, making early detection crucial for improving survival rates. Circulating tumor cells (CTC), detectable before primary tumors become clinically apparent, have emerged as vital biomarkers for the early identification of aggressive cancers. Here, develop a single‐atom nanozyme integrated nanoarray as a 3D nano‐biointerface for ultrasensitive electrochemical screening of CTCs from hepatocellular carcinoma. This cytosensor is capable of identifying CTC at a single‐cell level, achieving an impressive area under the curve of 0.96 in receiver operating characteristics, comparable to simulated multi‐indicator diagnostic strategies. This screening strategy shows great potential for the non‐invasive early detection of hepatocellular carcinoma and is promising to be applied universally to early cancer diagnosis.
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Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · MXene and MAX Phase Materials · Extracellular vesicles in disease
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Laboratory Medicine/Clinical Laboratory Medicine Research Center West China Hospital Sichuan University Chengdu Sichuan 610041 China
Sichuan Clinical Research Center for Laboratory Medicine Chengdu Sichuan 610041 China
Center for High Altitude Medicine, West China Hospital Sichuan University Chengdu Sichuan 610041 China
Department of Radiology and Huaxi MR Research Center (HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital Sichuan University Chengdu Sichuan 610041 China
Chinese Evidence‐Based Medicine Center West China Hospital Sichuan University Chengdu Sichuan 610041 China
Center for education of medical humanities West China Hospital Sichuan University Chengdu Sichuan 610041 China
College of Chemistry Chemical Engineering and Materials Science Shandong Normal University Jinan Shandong 250014 China
Funding
National Natural Science Foundation of China
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