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journal article·2024-04

Tumor Microenvironment‐Induced Drug Depository for Persistent Antitumor Chemotherapy and Immune Activation

Fan Gao, Chun Xue, Jianhui Dong, Xinxin Lu, Nan Yang, Changjin Ou, Xiaozhou Mou, Yi‐Zhou Zhang, Xiaochen Dong

Small· Volume 20· Issue 15
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Source abstract

Abstract

Abstract Herein, a drug‐loading nanosystem that can in situ form drug depository for persistent antitumor chemotherapy and immune regulation is designed and built. The system (DOX@MIL‐LOX@AL) is fabricated by packaging alginate on the surface of Doxorubicin (DOX) and lactate oxidase (LOX) loaded MIL‐101(Fe)‐NH2 nanoparticle, which can easily aggregate in the tumor microenvironment through the cross‐linking with intratumoral Ca2+. Benefiting from the tumor retention ability, the fast‐formed drug depository will continuously release DOX and Fe ions through the ATP‐triggered slow degradation, thus realizing persistent antitumor chemotherapy and immune regulation. Meanwhile, LOX in the non‐aggregated nanoparticles is able to convert the lactic acid to H2O2, which will be subsequently decomposed into ·OH by Fe ions to further enhance the DOX‐induced immunogenic death effect of tumor cells. Together, with the effective consumption of immunosuppressive lactic acid, long‐term chemotherapy, and oxidation therapy, DOX@MIL‐LOX@AL can execute high‐performance antitumor chemotherapy and immune activation with only one subcutaneous administration.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment Technology School of Environmental Science and Engineering Nanjing University of Information Science & Technology Nanjing 210044 China

Institute of Advanced Materials and Flexible Electronics (IAMFE) School of Chemistry and Materials Science Nanjing University of Information Science & Technology Nanjing 210044 China

Center for Rehabilitation Medicine Rehabilitation & Sports Medicine Research Institute of Zhejiang Province Department of Rehabilitation Medicine Cancer Center Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College Hangzhou Zhejiang 310014 China

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211816 China

School of Chemistry & Materials Science Jiangsu Normal University Xuzhou 221116 China

Funding

National Natural Science Foundation of China · Startup Foundation for Introducing Talent of Nanjing University of Information Science and Technology

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