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journal article·2023-12Open access

Ag2S Biocompatible Ensembles as Dual OCT Contrast Agents and NIR Ocular Imaging Probes

Amalia Coro, Ada Herrero Ruiz, Mateo Pazo‐González, Alonso Sánchez‐Cruz, Tobias Busch, Alejandro Hernández Medel, Erving C. Ximendes, Dirk H. Ortgies, Rosalía López‐Méndez, Ana Espinosa, Dorleta Jimenez de Aberasturi, Daniel Jaque, Nuria Fernández Monsalve, Enrique J. de la Rosa, Catalina Hernández‐Sánchez, Emma Martín Rodríguez, Beatriz H. Juárez

Small· Volume 19· Issue 49
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Source abstract

Abstract

Abstract Ag2S nanoparticles (NPs) emerge as a unique system that simultaneously features in vivo near‐infrared (NIR) imaging, remote heating, and low toxicity thermal sensing. In this work, their capabilities are extended into the fields of optical coherence tomography (OCT), as contrast agents, and NIR probes in both ex vivo and in vivo experiments in eyeballs. The new dual property for ocular imaging is obtained by the preparation of Ag2S NPs ensembles with a biocompatible amphiphilic block copolymer. Rather than a classical ligand exchange, where surface traps may arise due to incomplete replacement of surface sites, the use of this polymer provides a protective extra layer that preserves the photoluminescence properties of the NPs, and the procedure allows for the controlled preparation of submicrometric scattering centers. The resulting NPs ensembles show extraordinary colloidal stability with time and biocompatibility, enhancing the contrast in OCT with simultaneous NIR imaging in the second biological window.
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Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Retinal and Optic Conditions · Quantum Dots Synthesis And Properties · Corneal Surgery and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Instituto de Ciencia de Materiales de Madrid CSIC C/ Sor Juana Inés de la Cruz, 3 28049 Madrid Spain

CiCbiomaGUNE Basque Research and Technology Alliance (BRTA) Miramon Pasealekua, 182 20014 Donostia‐San Sebastián Gipuzkoa Spain

Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y, Nanomedicina (CIBER‐BBN) 20014 Donostia‐San Sebastián Spain

Centro de Investigaciones Biológicas Margarita Salas CSIC C/ Ramiro de Maeztu, 9 28040 Madrid Spain

Department of Systems Biology, Facultad de Medicina Universidad de Alcalá Ctra de Madrid‐Barcelona, Km 33,600 Alcalá de Henares 28871 Madrid Spain

Visual Neurophysiology Group Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) Ctra. Colmenar Viejo, km. 9,100 28034 Madrid Spain

Nanomaterials for BioImaging Group (nanoBIG) Facultad de Ciencias Universidad Autónoma de Madrid C/ Francisco Tomás y Valiente 7 28049 Madrid Spain

Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) Ctra. Colmenar Viejo, km. 9,100 28034 Madrid Spain

Institute for Advanced Research in Chemistry (IAdChem) Campus de Cantoblanco 28049 Madrid Spain

Instituto Nicolás Cabrera Facultad de Ciencias Universidad Autónoma de Madrid C/ Francisco Tomás y Valiente 7 28049 Madrid Spain

Instituto IMDEA Nanociencia C/ Faraday, 9 28049 Madrid Spain

Ikerbasque Basque Foundation for Science 48009 Bilbao Spain

nanoBIG Group Facultad de Medicina Universidad Autónoma de Madrid C/ Arzobispo Morcillo, 4 28029 Madrid Spain

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) ISCIII 28034 Madrid Spain

Funding

Ministerio de Ciencia e Innovación · Instituto de Salud Carlos III · Comunidad de Madrid · Universidad Autónoma de Madrid

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