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journal article·2024-11Open access

Ultra‐Microporous Fe‐MOF with Prolonged NO Delivery in Biological Media for Therapeutic Application

Rosana V. Pinto, Chen‐Chen Cao, Pengbo Lyu, Iurii Dovgaliuk, William Shepard, Eric Rivière, Cheng‐Yong Su, Guillaume Maurin, Fernando Antunes, João Pires, Vânia André, Carlos Henriques, Antoine Tissot, Moisés L. Pinto, Christian Serre

Small· Volume 20· Issue 48
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Abstract

Abstract Nitric oxide (NO), a key element in the regulation of essential biological mechanisms, presents huge potential as therapeutic agent in the treatment and prevention of chronic diseases. Metal‐organic frameworks (MOFs) with open metal sites are promising carriers for NO therapies but delivering it over an extended period in biological media remains a great challenge due to i) a fast degradation of the material in body fluids and/or ii) a rapid replacement of NO by water molecules onto the Lewis acid sites. Here, a new ultra‐narrow pores Fe bisphosphonate MOF, denoted MIP‐210(Fe) or Fe(H2O)(Hmbpa) (H4mbpa = p‐xylenediphosphonic acid) is described that adsorbs NO due to an unprecedented sorption mechanism: coordination of NO through the Fe(III) sites is unusually preferred, replacing bound water, and creating a stable interaction with the free H2O and P‐OH groups delimiting the ultra‐narrow pores. This, associated with the high chemical stability of the MOF in body fluids, enables an unprecedented slow replacement of NO by water molecules in biological media, achieving an extraordinarily extended NO delivery time over at least 70 h, exceeding by far the NO kinetics release reported with others porous materials, paving the way for the development of safe and successful gas therapies.
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Research context

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis

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Affiliations

CERENA Departamento de Engenharia Química Instituto Superior Técnico Universidade de Lisboa Lisboa 1049‐001 Portugal

CQE ‐Centro de Química Estrutural Institute of Molecular Sciences Departamento de Química e Bioquímica Faculdade de Ciências Universidade de Lisboa Lisboa 1749‐016 Portugal

Institut des Matériaux Poreux de Paris Ecole Normale Supérieure ESPCI Paris CNRS PSL University Paris 75005 France

MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou 510275 China

ICGM Univ. Montpellier CNRS ENSCM Montpellier 34293 France

Hunan Provincial Key Laboratory of Thin Film Materials and Devices School of Materials Science and Engineering Xiangtan University Xiangtan 411105 China

Synchrotron SOLEIL L'Orme des Merisiers Départementale 128 Saint‐Aubin 91190 France

Institut de Chimie Moléculaire et des Matériaux d'Orsay Université Paris‐Saclay CNRS ICMMO Orsay Cedex 91405 France

State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

CQE – Centro de Química Institute of Molecular Sciences Instituto Superior Técnico Universidade de Lisboa Av. Rovisco Pais Lisboa 1049‐001 Portugal

Funding

Fundação para a Ciência e a Tecnologia · Natural Science Foundation of Hunan Province · China Postdoctoral Science Foundation

References (49)

Show source-provided references
1. 10.1039/c2cs15273h10.1039/c2cs15273h ↗
2. 10.1038/327524a010.1038/327524a0 ↗
3. 10.1152/ajpcell.00315.201610.1152/ajpcell.00315.2016 ↗
4. 10.1039/D0CC03740K10.1039/D0CC03740K ↗
5. 10.1002/anie.20191313510.1002/anie.201913135 ↗
6. 10.1021/acsami.1c1724810.1021/acsami.1c17248 ↗
7. 10.1021/acsami.0c0179210.1021/acsami.0c01792 ↗
8. 10.1021/acsami.6b1493710.1021/acsami.6b14937 ↗
9. 10.1021/ja210771m10.1021/ja210771m ↗
10. 10.1063/1.490406910.1063/1.4904069 ↗
11. 10.1021/ja801997r10.1021/ja801997r ↗
12. 10.1016/j.mtcomm.2017.07.00710.1016/j.mtcomm.2017.07.007 ↗
13. 10.1002/cmdc.20210042910.1002/cmdc.202100429 ↗
14. J.Pant M. J.Goudie E. J.Brisbois H.Handa (Eds.:S. L.Cooper J. B. T.‐A. in P. B.Guan) Woodhead Publishing 2016 pp.417–449.10.1016/B978-0-08-100614-6.00014-7 ↗
15. 10.3390/molecules2703067410.3390/molecules27030674 ↗
16. 10.1016/j.ccr.2023.21505210.1016/j.ccr.2023.215052 ↗
17. 10.1039/D1QM00784J10.1039/D1QM00784J ↗
18. 10.1021/ja513224310.1021/ja5132243 ↗
19. 10.1021/cm052149l10.1021/cm052149l ↗
20. 10.1039/D1NJ02841C10.1039/D1NJ02841C ↗
21. 10.1021/cr200225710.1021/cr2002257 ↗
22. 10.1002/zaac.20050048310.1002/zaac.200500483 ↗
23. 10.1021/ic050226910.1021/ic0502269 ↗
24. 10.1002/cssc.20160181610.1002/cssc.201601816 ↗
25. K. D.Demadis N.Stavgianoudaki inMetal Phosphonate Chemistry: From Synthesis to Applications ed.A.Clearfield andK.Demadis The Royal Society of Chemistry 2011 ch. 14 pp.438‐492.10.1039/9781849733571-00438 ↗
26. R. V.Pinto M. L.Pinto inNanoporous Materials: New Generation of Nitric Oxide Donors ed.L.Morbidelli B.Bonavida Academic Press 2019 ch. 14 pp.277–305.10.1016/B978-0-12-816545-4.00014-1 ↗
27. 10.1039/c3cc41987h10.1039/c3cc41987h ↗
28. 10.1021/cm304037x10.1021/cm304037x ↗
29. 10.1081/CR-10010026010.1081/CR-100100260 ↗
30. 10.1063/1.132967210.1063/1.1329672 ↗
31. “Vasp TST tools” downloaded from:http://theory.cm.utexas.edu/vtsttools(accessed: January 2022).
32. 10.1021/ic500558j10.1021/ic500558j ↗
33. 10.1021/ja050357910.1021/ja0503579 ↗
34. 10.1016/j.niox.2019.05.01010.1016/j.niox.2019.05.010 ↗
35. 10.1016/j.micromeso.2021.11115410.1016/j.micromeso.2021.111154 ↗
36. Feelisch M. · 1996 · 455
37. 10.1016/j.actbio.2018.05.02510.1016/j.actbio.2018.05.025 ↗
38. 10.1016/j.ijbiomac.2015.04.07310.1016/j.ijbiomac.2015.04.073 ↗
39. 10.1016/j.actbio.2017.03.01110.1016/j.actbio.2017.03.011 ↗
40. 10.1088/1742-6596/304/1/01204510.1088/1742-6596/304/1/012045 ↗
41. 10.1039/c3sc22116d10.1039/c3sc22116d ↗
42. 10.1161/01.STR.23.11.163710.1161/01.STR.23.11.1637 ↗
43. 10.1007/s40820-020-00542-x10.1007/s40820-020-00542-x ↗
44. 10.1021/acsanm.2c0159110.1021/acsanm.2c01591 ↗
45. 10.1039/D0MA00650E10.1039/D0MA00650E ↗
46. 10.1021/acsami.0c1793710.1021/acsami.0c17937 ↗
47. 10.1038/nmat91310.1038/nmat913 ↗
48. 10.1021/acsami.3c1128310.1021/acsami.3c11283 ↗
49. 10.1016/B978-0-12-816545-4.00004-910.1016/B978-0-12-816545-4.00004-9 ↗