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journal article·2022-03

Ionic Current Fluctuation and Orientation of Tetrahedral DNA Nanostructures in a Solid‐State Nanopore

Xiaoyu Chen, Xinjia Zhao, Ruiping Ma, Ying Hu, Chengjun Cui, Zhuang Mi, Ruifen Dou, Dun Pan, Xinyan Shan, Lihua Wang, Chunhai Fan, Xinghua Lu

Small· Volume 18· Issue 12
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Source abstract

Abstract

Abstract Understanding the dynamic behavior of a nanostructure translocating through a nanopore is important for various applications. In this paper, the characteristics in ion current traces of tetrahedral DNA nanostructures (TDN) translocating through a solid‐state nanopore are examined, by combined experimental and theoretical simulations. The results of finite element analysis reveal the correlation between orientation of TDN and the conductance blockade. The experimentally measured fluctuations in the conductance blockade, expressed as voltage‐dependent histogram profiles, are consistent with the simulation, revealing the nature of a random distribution in orientation and weak influence of electrostatic and viscous torques. The step changes in orientation of a TDN during translocation are further explained by the collision with the nanopore, while the gradual changes in orientation illustrate the impact of a weak torque field in the nano‐fluidic channel. The results demonstrate a general method and basic understanding in the dynamic behavior of nanostructures translocating through solid‐state nanopores.
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Research context

Nanomaterials

OpenAlex topics: Nanopore and Nanochannel Transport Studies · Fuel Cells and Related Materials · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing National Laboratory for Condensed‐Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China

School of Physical Sciences University of Chinese Academy of Sciences Beijing 100190 China

Beijing Normal University Beijing 100088 China

Shanghai Frontier Innovation Research Institute Shanghai 201108 China

Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Bio‐X Institutes Shanghai Jiao Tong University Shanghai Shanghai 200030 China

Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201210 China

School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200240 China

Songshan Lake Materials Laboratory Dongguan Guangdong 523808 China

Center for Excellence in Topological Quantum Computation Beijing 100190 China

Funding

National Natural Science Foundation of China

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