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journal article·2024-08Open access

Injectable Self‐Oxygenating Cardio‐Protective and Tissue Adhesive Silk‐Based Hydrogel for Alleviating Ischemia After Mi Injury

Shabir Hassan, Zahra Rezaei, Eder Luna, Dilara Yilmaz‐Aykut, Myung Chul Lee, Ana Marie Perea, Anurag Jamaiyar, Nicole Bassous, Minoru Hirano, Fatima Mumtaza Tourk, Cholong Choi, Malin Becker, Iman Yazdi, Kai Fan, Alan Eduardo Avila‐Ramirez, David Ge, Reza Abdi, Sudeshna Fisch, Jeroen Leijten, Mark W. Feinberg, Biman B. Mandal, Ronglih Liao, Su Ryon Shin

Small· Volume 20· Issue 32
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Source abstract

Abstract

Abstract Myocardial infarction (MI) is a significant cardiovascular disease that restricts blood flow, resulting in massive cell death and leading to stiff and noncontractile fibrotic scar tissue formation. Recently, sustained oxygen release in the MI area has shown regeneration ability; however, improving its therapeutic efficiency for regenerative medicine remains challenging. Here, a combinatorial strategy for cardiac repair by developing cardioprotective and oxygenating hybrid hydrogels that locally sustain the release of stromal cell‐derived factor‐1 alpha (SDF) and oxygen for simultaneous activation of neovascularization at the infarct area is presented. A sustained release of oxygen and SDF from injectable, mechanically robust, and tissue‐adhesive silk‐based hybrid hydrogels is achieved. Enhanced endothelialization under normoxia and anoxia is observed. Furthermore, there is a marked improvement in vascularization that leads to an increment in cardiomyocyte survival by ≈30% and a reduction of the fibrotic scar formation in an MI animal rodent model. Improved left ventricular systolic and diastolic functions by ≈10% and 20%, respectively, with a ≈25% higher ejection fraction on day 7 are also observed. Therefore, local delivery of therapeutic oxygenating and cardioprotective hydrogels demonstrates beneficial effects on cardiac functional recovery for reparative therapy.
Source: crossref · Quality: baseline

Research context

Polymers

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine Harvard Medical School 65 Landsdowne St Cambridge 02139 United States

Department of Biological Sciences Khalifa University Shakhbout Bin Sultan St Abu Dhabi 127788 United Arab Emirates

Biotechnology Center (BTC) Khalifa University Shakhbout Bin Sultan St Abu Dhabi 127788 United Arab Emirates

Department of Chemical Engineering Sharif University of Technology Tehran 1365‐11155 Iran

Department of Chemical Engineering Faculty of Engineering Istanbul University‐Cerrahpaşa Istanbul 34320 Turkey

Biomedical Research Division Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST) Seoul South Korea

School of Science and Engineering, Technologico de Monterrey Monterrey Mexico

Division of Cardiovascular Medicine Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA 02115 USA

Future Vehicle Research Department Toyota Research Institute North America Toyota Motor North America, Inc. 1555 Woodridge Ave. Ann Arbor MI 48105 USA

Department of Mechanical Engineering Northeastern University Boston MA 02115 USA

Department of BioEngineering Technologies Faculty of Science and Technology Technical Medical Centre University of Twente Drienerlolaan 5 Enschede 7522 NB The Netherlands

School of Arts and Sciences Regis College 235 Wellesley Street Weston MA 02493 USA

School of Automation Hangzhou Dianzi Hangzhou Zhejiang 310018 China

Division of Biological and Environmental Science Engineering (BESE) King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi Arabia

Transplantation Research Center Renal Division Brigham and Women's Hospital / Harvard Medical School Boston MA 02115 USA

Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati Guwahati Assam 781039 India

Center for nanotechnology Indian Institute of Technology Guwahati (IITG) Guwahati Assam 781039 India

Jyoti and Bhupat Mehta School of health Sciences and Technology, Indian Institute of Technology Guwahati (IITG) Guwahati Assam 781039 India

School of Medicine Stanford University Stanford CA 94305‐5101 USA

Stanford Amyloid Center Stanford University Stanford CA 94305‐5101 USA

Funding

American Heart Association · National Institutes of Health · Khalifa University of Science, Technology and Research

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