A Smart Bacteria‐Capture‐Killing Vector for Effectively Treating Osteomyelitis Through Synergy Under Microwave Therapy

Abstract Osteomyelitis caused by deep tissue infections is difficult to cure through phototherapy due to the poor penetration depth of the light. Herein, Cu/C/Fe₃O₄‐COOH nanorod composites (Cu/C/Fe₃O₄‐COOH) with nanoscale tip convex structures are successfully fabricated as a microwave‐responsive smart bacteria‐capture‐killing vector. Cu/C/Fe₃O₄‐COOH exhibited excellent magnetic targeting and bacteria‐capturing ability due to its magnetism and high selectivity affinity to the amino groups on the surface of Staphylococcus aureus (S. aureus). Under microwave irradiation, Cu/C/Fe₃O₄‐COOH efficiently treated S. aureus‐infected osteomyelitis through the synergistic effects of microwave thermal therapy, microwave dynamic therapy, and copper ion therapy. It is calculated the electric field intensity in various regions of Cu/C/Fe₃O₄‐COOH under microwave irradiation, demonstrating that it obtained the highest electric field intensity on the surface of copper nanoparticles of Cu/C/Fe₃O₄‐COOH due to its high‐curvature tips and metallic properties. This led to copper nanoparticles attracted more charged particles compared with other areas in Cu/C/Fe₃O₄‐COOH. These charges are easier to escape from the high curvature surface of Cu/C/Fe₃O₄‐COOH, and captured by adsorbed oxygen, resulting in the generation of reactive oxygen species. The Cu/C/Fe₃O₄‐COOH designed in this study is expected to provide insight into the treatment of deep tissue infections under the irradiation of microwave.