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journal article·2024-05-07

Synergistic Effects of Matrix Biophysical Properties on Gastric Cancer Cell Behavior via Integrin‐Mediated Cell‐ECM Interactions

Cailan Xiao, Ning Xie, Qiuai Shu, Xiru Liang, Ziwei Wang, Jian Wu, Nianyuan Shi, Xindi Huang, Zhong‐Cao Wei, Xiaoliang Gao, Hao Liu, Kaichun Wu, Jingyuan Xu, Jin‐Hai Wang, Na Liu, Feng Xu

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Abstract

Abstract The biophysical properties of the extracellular matrix (ECM) play a pivotal role in modulating cancer progression via cell‐ECM interactions. However, the biophysical properties specific to gastric cancer (GC) remain largely unexplored. Pertinently, GC ECM shows significantly heterogeneous metamorphoses, such as matrix stiffening and intricate restructuring. By combining collagen I and alginate, this study designs an in vitro biomimetic hydrogel platform to independently modulate matrix stiffness and structure across a physiological stiffness spectrum while preserving consistent collagen concentration and fiber topography. With this platform, this study assesses the impacts of matrix biophysical properties on cell proliferation, migration, invasion, and other pivotal dynamics of AGS. The findings spotlight a compelling interplay between matrix stiffness and structure, influencing both cellular responses and ECM remodeling. Furthermore, this investigation into the integrin/actin‐collagen interplay reinforces the central role of integrins in mediating cell‐ECM interactions, reciprocally sculpting cell conduct, and ECM adaptation. Collectively, this study reveals a previously unidentified role of ECM biophysical properties in GC malignant potential and provides insight into the bidirectional mechanical cell‐ECM interactions, which may facilitate the development of novel therapeutic horizons.
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Research context

PolymersComposites

OpenAlex topics: Cellular Mechanics and Interactions · Cell Adhesion Molecules Research · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Gastroenterology the Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710049 P. R. China

The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an Shaanxi 710049 P. R. China

Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University Xi'an Shaanxi 710049 P. R. China

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Xijing Hospital of Digestive Diseases Air Force Military Medical University Xi'an Shaanxi 710032 P. R. China

National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Key Laboratory of Magnetic Medicine, Department of Hepatobiliary Surgery the First Affiliated Hospital of Xi’an Jiaotong University Xi'an Shaanxi 710061 China

Department of Gastroenterology the Affiliated Suzhou Hospital of Nanjing Medical University Suzhou 215001 P. R. China

Department of Gastroenterology Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) Haikou 570311 P. R. China

Funding

National Natural Science Foundation of China

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