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journal article·2024-03

Adipose Tissue Targeting Ultra‐Small Hybrid Nanoparticles for Synergistic Photodynamic Therapy and Browning Induction in Obesity Treatment

Chuan Ma, Chuanjiang Jian, Lihao Guo, Wenting Li, Cai Zhang, Li Wang, Miaomiao Yuan, Peng Zhang, Jinqiao Dong, Ping He, Leilei Shi

Small· Volume 20· Issue 13
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Source abstract

Abstract

Abstract Photodynamic therapy (PDT), as a means of locally and rapidly inducing adipocyte death via light illumination, in combination with adipose browning induction, a more gradual and widespread effect that could transform white adipose tissue into thermogenic adipose tissue, manifests a promising approach to combat obesity. Herein, adipose‐targeting ultra‐small hybrid nanoparticles (Pep‐PPIX‐Baic NPs) composed of an adipose‐targeting peptide, Fe3+, a photosensitizer (protoporphyrin IX), and a browning agent (baicalin) are introduced. Pep‐PPIX‐Baic NPs have been designed to simultaneously enhance the photodynamic effect and induce browning. After intravenous injection in obese mice, the hybrid nanoparticles can specifically accumulate in white adipose tissues, especially those rich in blood supply, and drive adipose reduction owing to the synergy of the PDT effect and baicalin browning induction. Overall, Pep‐PPIX‐Baic NPs exhibited superior anti‐obesity potential through PDT synergistic with adipose browning induction. The designed multifunctional adipose‐targeting hybrid nanoparticles present a prospective nanoplatform for obesity treatment.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer, Stress, Anesthesia, and Immune Response · Adipose Tissue and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Cheeloo College of Medicine Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Jinan 250012 China

Department of Pharmacology The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 China

Precision Research Center for Refractory Diseases Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 201600 China

Department of Pharmacy The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University 47 Youyi Road Shenzhen 518001 China

School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Natural Science Foundation of Shandong Province

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