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journal article·2023-11Open access

Molecular Engineering of AIE Photosensitizers for Inactivation of Rabies Virus

Yujie Bai, Eric Y. Yu, Yongsai Liu, Hongli Jin, Xingqi Liu, Xiaoyu Wu, Mengyao Zhang, Na Feng, Pei Huang, Haili Zhang, Ryan. T. K. Kwok, Xianzhu Xia, Yuanyuan Li, Ben Zhong Tang, Hualei Wang

Small· Volume 19· Issue 45
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Abstract

Abstract Rabies is a zoonotic neurological disease caused by the rabies virus (RABV) that is fatal to humans and animals. While several post‐infection treatment have been suggested, developing more efficient and innovative antiviral methods are necessary due to the limitations of current therapeutic approaches. To address this challenge, a strategy combining photodynamic therapy and immunotherapy, using a photosensitizer (TPA‐Py‐PhMe) with high type I and type II reactive oxygen species (ROS) generation ability is proposed. This approach can inactivate the RABV by killing the virus directly and activating the immune response. At the cellular level, TPA‐Py‐PhMe can reduce the virus titer under preinfection prophylaxis and postinfection treatment, with its antiviral effect mainly dependent on ROS and pro‐inflammatory factors. Intriguingly, when mice are injected with TPA‐Py‐PhMe and exposed to white light irradiation at three days post‐infection, the onset of disease is delayed, and survival rates improved to some extent. Overall, this study shows that photodynamic therapy and immunotherapy open new avenues for future antiviral research.
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Research context

OpenAlex topics: Rabies epidemiology and control · Nanoplatforms for cancer theranostics · Virus-based gene therapy research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis and College of Veterinary Medicine Jilin University Changchun 130062 China

Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay, Kowloon Hong Kong 999077 China

Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Changchun 130122 China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Shenzhen Guangdong 518172 China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Innovation and Technology Commission

References (55)

Show source-provided references
1. WHO World Health Organ. Tech. Rep. Ser 2013 1.
2. 10.1038/nrdp.2017.9110.1038/nrdp.2017.91 ↗
3. 10.1007/s00401-015-1511-310.1007/s00401-015-1511-3 ↗
4. Singh R. · Vet. J. · 2017 · 37 · 212
5. 10.1016/j.vaccine.2009.06.03010.1016/j.vaccine.2009.06.030 ↗
6. Groaz E. · 2021 · 49
7. 10.1099/jgv.0.00126910.1099/jgv.0.001269 ↗
8. 10.1016/j.coviro.2018.12.00910.1016/j.coviro.2018.12.009 ↗
9. 10.1128/JVI.01964-0610.1128/JVI.01964-06 ↗
10. 10.1002/anie.20200747410.1002/anie.202007474 ↗
11. 10.1038/s41573-021-00139-y10.1038/s41573-021-00139-y ↗
12. 10.1016/j.biomaterials.2019.11949110.1016/j.biomaterials.2019.119491 ↗
13. 10.1126/scitranslmed.aay135910.1126/scitranslmed.aay1359 ↗
14. 10.1002/ange.20190970610.1002/ange.201909706 ↗
15. 10.1021/cr900236h10.1021/cr900236h ↗
16. 10.1016/j.biomaterials.2020.11982710.1016/j.biomaterials.2020.119827 ↗
17. 10.1039/D1BM01780B10.1039/D1BM01780B ↗
18. 10.1039/C7CS00594F10.1039/C7CS00594F ↗
19. Sun Q. · Aggregate · 2022 · 4 · 1
20. 10.1021/acsnano.0c0593710.1021/acsnano.0c05937 ↗
21. 10.1002/smll.20210177010.1002/smll.202101770 ↗
22. 10.1016/j.chempr.2020.06.02410.1016/j.chempr.2020.06.024 ↗
23. 10.1002/adfm.20200205710.1002/adfm.202002057 ↗
24. 10.1002/smll.20200674210.1002/smll.202006742 ↗
25. 10.1021/jacs.1c0747910.1021/jacs.1c07479 ↗
26. 10.1002/agt2.710.1002/agt2.7 ↗
27. Zhang C. · Adv. Healthcare Mater. · 2023
28. 10.1111/imr.1262110.1111/imr.12621 ↗
29. 10.1016/j.neuron.2020.08.01210.1016/j.neuron.2020.08.012 ↗
30. 10.1038/ni.365610.1038/ni.3656 ↗
31. 10.1007/s11481-013-9480-610.1007/s11481-013-9480-6 ↗
32. 10.1016/j.virusres.2009.03.01410.1016/j.virusres.2009.03.014 ↗
33. Yang J. · Front Mol Neurosci · 2022
34. 10.1007/s00705-018-3808-810.1007/s00705-018-3808-8 ↗
35. 10.1128/JVI.01346-0910.1128/JVI.01346-09 ↗
36. 10.2217/imt-2016-002010.2217/imt-2016-0020 ↗
37. 10.1126/science.abb892510.1126/science.abb8925 ↗
38. 10.1038/nri.2017.3610.1038/nri.2017.36 ↗
39. 10.1126/science.abi520010.1126/science.abi5200 ↗
40. 10.1002/adma.20200321010.1002/adma.202003210 ↗
41. 10.3390/nano1111313210.3390/nano11113132 ↗
42. 10.1021/acsami.1c1459810.1021/acsami.1c14598 ↗
43. 10.1021/acs.nanolett.8b0240910.1021/acs.nanolett.8b02409 ↗
44. 10.1111/php.1325310.1111/php.13253 ↗
45. 10.1038/s41568-020-0281-y10.1038/s41568-020-0281-y ↗
46. 10.1038/nri285110.1038/nri2851 ↗
47. 10.1016/B978-0-7020-6896-6.00025-910.1016/B978-0-7020-6896-6.00025-9 ↗
48. 10.1039/C6CS00616G10.1039/C6CS00616G ↗
49. 10.1002/adhm.20170135710.1002/adhm.201701357 ↗
50. 10.1021/acs.nanolett.2c0298310.1021/acs.nanolett.2c02983 ↗
51. 10.1002/adfm.20210359110.1002/adfm.202103591 ↗
52. 10.1038/s41467-019-08680-610.1038/s41467-019-08680-6 ↗
53. 10.1002/advs.20220546110.1002/advs.202205461 ↗
54. 10.1016/j.cej.2021.12855710.1016/j.cej.2021.128557 ↗
55. 10.1021/jacs.1c0915510.1021/jacs.1c09155 ↗