Triple Constructs Consisting of Nanoparticles and Microspheres for Bone‐Marrow‐Derived Stromal‐Cell‐Delivery Microscaffolds

The effective stabilization of 2- and 3D assemblies of heparin/poly(l-lysine) nanoparticles is achieved through embedment in DHEA- and DEXA-loaded poly(l-lactic-co-glycolic acid) (PLGA) microspheres (see image). These structures, which have great potential for use in cell delivery and for tissue regeneration, are manufactured using layer-by-layer electrostatic self-assembly, and are shown to have a positive effect on bone-marrow stromal cell aggregation and differentiation. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.