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journal article·2020-02Open access

Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

Feifei Yang, Yusra Medik, Liantao Li, Xi Tian, Dong Fu, Kim L. R. Brouwer, Kyle Wagner, Bo Sun, Hossein Sendi, Yu Mi, Andrew Z. Wang

Small· Volume 16· Issue 7
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Source abstract

Abstract

Abstract Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical‐stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can contribute to the hepatotoxicity of nanotherapeutics beyond the intrinsic hepatotoxicity of nanoparticles (NPs) are poorly understood. Because of this knowledge gap, clinical translation efforts have avoided hepatotoxic molecules. By examining the hepatotoxicity of nanoformulations of known hepatotoxic compounds, it is demonstrated that nanotherapeutics are associated with lower hepatotoxicity than their small‐molecule counterparts. It is also found that the reduced hepatotoxicity is related to the uptake of nanotherapeutics by macrophages in the liver. These findings can facilitate further development and clinical translation of nanotherapeutics.
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Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoparticles: synthesis and applications · Curcumin's Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences & Peking Union Medical College Haidian District Beijing 100193 P. R. China

Laboratory of Nano‐ and Translational Medicine Lineberger Comprehensive Cancer Center Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer Institute Xuzhou Medical University Xuzhou Jiangsu 221004 P. R. China

UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Funding

National Institutes of Health · National Cancer Institute · Chinese Academy of Meteorological Sciences · University of North Carolina at Chapel Hill · U.S. Department of Defense

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