DataVXACS NanoPaper
journal article·2021-08-24

Nitric Oxide Nanomotor Driving Exosomes-Loaded Microneedles for Achilles Tendinopathy Healing

Anlong Liu, Qi Wang, Zinan Zhao, Rui Wu, Maochun Wang, Jiawei Li, Kuoyang Sun, Ziying Sun, Zhongyang Lv, Jia Xu, Huiming Jiang, Mimi Wan, Dongquan Shi, Chun Mao

ACS Nano· Volume 15· Issue 8
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Source abstract

Abstract

The microneedle (MN) provides a promising strategy for transdermal delivery of exosomes (EXO), in which the therapeutic effects and clinical applications are greatly reduced by the fact that EXO can only partially reach the injury site by passive diffusion. Here, we designed a detachable MN array to deliver EXO modified by a nitric oxide nanomotor (EXO/MBA) for Achilles tendinopathy (AT) healing. With the releasing of EXO/MBA, l-arginine was converted to nitric oxide by NOS or ROS as the driving force. Benefiting from the motion ability and the property of MPC tending to lower pH, EXO could accumulate at the injury site more efficiently. This work demonstrated that EXO/MBA-loaded MN notably suppressed the inflammation of AT, facilitated the proliferation of tendon cells, increased the expression of Col1a, and prevented extracellular matrix degradation, indicating its potential value in enthesiopathy healing and other related biomedical fields.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Tendon Structure and Treatment · Advancements in Transdermal Drug Delivery · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu, People’s Republic of China

National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China

Funding

Ministry of Science and Technology of the People's Republic of China · China Postdoctoral Science Foundation · Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Jiangsu Provincial Key Medical Talent Foundation · Six Talent Peaks Project of Jiangsu Province

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