DataVXACS NanoPaper
journal article·2015-10-27Open access

Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell–Nanoparticle Interaction

Lu Zhang, Qiang Feng, Jiuling Wang, Shuai Zhang, Baoquan Ding, Yujie Wei, Mingdong Dong, Ji-Young Ryu, Tae-Young Yoon, Xinghua Shi, Jiashu Sun, Xingyu Jiang

ACS Nano· Volume 9· Issue 10
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Source abstract

Abstract

The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell-particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell-particle interaction may have important implications for designing drug nanocarriers.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Lipid Membrane Structure and Behavior · Nanopore and Nanochannel Transport Studies · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China

State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China

Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark

National Creative Research Initiative Center for Single-Molecule Systems Biology and Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea

Funding

Chinese Academy of Sciences · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China

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