DataVXACS NanoPaper
journal article·2018-07-24Open access

Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier

Alysia Cox, Patrizia Andreozzi, Roberta Dal Magro, Fabio Fiordaliso, Alessandro Corbelli, Laura Talamini, Clizia Chinello, Francesca Raimondo, Fulvio Magni, Maria Tringali, Silke Krol, Paulo Jacob Silva, Francesco Stellacci, Massimo Masserini, Francesca Re

ACS Nano· Volume 12· Issue 7
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Source abstract

Abstract

Engineered nanoparticles offer the chance to improve drug transport and delivery through biological barriers, exploiting the possibility to leave the blood circulation and traverse the endothelial vascular bed, blood-brain barrier (BBB) included, to reach their target. It is known that nanoparticles gather molecules on their surface upon contact with biological fluids, forming the "protein corona", which can affect their fate and therapeutic/diagnostic performance, yet no information on the corona's evolution across the barrier has been gathered so far. Using a cellular model of the BBB and gold nanoparticles, we show that the composition of the corona undergoes dramatic quantitative and qualitative molecular modifications during passage from the "blood" to the "brain" side, while it is stable once beyond the BBB. Thus, we demonstrate that the nanoparticle corona dynamically and drastically evolves upon crossing the BBB and that its initial composition is not predictive of nanoparticle fate and performance once beyond the barrier at the target organ.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Gold and Silver Nanoparticles Synthesis and Applications · Protein Interaction Studies and Fluorescence Analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Medicine and Surgery, Nanomedicine Center NANOMIB, University of Milano-Bicocca, Via Raoul Follereau 3, 20854 Vedano al Lambro (MB), Italy

IFOM−FIRC Institute of Molecular Oncology, IFOM−IEO Campus, Milan 20139, Italy

CICbiomaGUNE, Soft Matter Nanotechnology Group, San Sebastian-Donostia, 20014 Guipuzcoa, Spain

IRCCS Institute of Pharmacological Research “Mario Negri″, Milan 20139, Italy

Department of Environmental Sciences, University of Milano-Bicocca, Milan 20126, Italy

IRCCS Foundation Institute for Neurology “Carlo Besta”, IFOM-IEO Campus, Milan 20139, Italy

IRCCS Cancer Institute “Giovanni Paolo II”, Bari 70021, Italy

Institute of Materials, École Polytechnique Fédérale de Lausanne, Lausanne1000, Switzerland

Interfaculty Bioengineering Institute, École Polytechnique Fédérale de Lausanne, Lausanne 1000, Switzerland

Funding

H2020 Health

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