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journal article·2022-04Open access

3D‐Printed Micro Lens‐in‐Lens for In Vivo Multimodal Microendoscopy

Jiawen Li, Simon Thiele, Rodney W. Kirk, Bryden C. Quirk, Ayla Hoogendoorn, Yung Chih Chen, Karlheinz Peter, Stephen J. Nicholls, Johan W. Verjans, Peter J. Psaltis, Christina Bursill, Alois M. Herkommer, Harald Giessen, Robert A. McLaughlin

Small· Volume 18· Issue 17
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Abstract

Abstract Multimodal microendoscopes enable co‐located structural and molecular measurements in vivo, thus providing useful insights into the pathological changes associated with disease. However, different optical imaging modalities often have conflicting optical requirements for optimal lens design. For example, a high numerical aperture (NA) lens is needed to realize high‐sensitivity fluorescence measurements. In contrast, optical coherence tomography (OCT) demands a low NA to achieve a large depth of focus. These competing requirements present a significant challenge in the design and fabrication of miniaturized imaging probes that are capable of supporting high‐quality multiple modalities simultaneously. An optical design is demonstrated which uses two‐photon 3D printing to create a miniaturized lens that is simultaneously optimized for these conflicting imaging modalities. The lens‐in‐lens design contains distinct but connected optical surfaces that separately address the needs of both fluorescence and OCT imaging within a lens of 330 µm diameter. This design shows an improvement in fluorescence sensitivity of >10x in contrast to more conventional fiber‐optic design approaches. This lens‐in‐lens is then integrated into an intravascular catheter probe with a diameter of 520 µm. The first simultaneous intravascular OCT and fluorescence imaging of a mouse artery in vivo is reported.
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Research context

Materials processing

OpenAlex topics: Optical Coherence Tomography Applications · Coronary Interventions and Diagnostics · Retinal and Macular Surgery

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Affiliations

Australian Research Council Centre of Excellence for Nanoscale BioPhotonics University of Adelaide Adelaide SA 5005 Australia

School of Electrical and Electronic Engineering University of Adelaide Adelaide SA 5005 Australia

Institute for Photonics and Advanced Sensing The University of Adelaide Adelaide SA 5005 Australia

Institute of Applied Optics (ITO) and Research Center SCoPE University of Stuttgart 70569 Stuttgart Germany

School of Biomedicine University of Adelaide Adelaide SA 5005 Australia

Lifelong Health Theme South Australian Health and Medical Research Institute (SAHMRI) Adelaide SA 5000 Australia

Baker Heart and Diabetes Institute Melbourne VIC 3004 Australia

Department of Cardiometabolic Health Bio21 Institute, Melbourne Medical School University of Melbourne Parkville VIC 3052 Australia

Victorian Heart Institute Monash University Melbourne VIC 3168 Australia

Department of Cardiology Royal Adelaide Hospital Adelaide SA 5000 Australia

Adelaide Medical School University of Adelaide Adelaide SA 5005 Australia

4th Physics Institute and Research Center SCoPE University of Stuttgart 70569 Stuttgart Germany

Funding

National Health and Medical Research Council · Australian Research Council · Bundesministerium für Bildung und Forschung · European Research Council · Deutsche Forschungsgemeinschaft · National Heart Foundation of Australia

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