DataVXACS NanoPaper
journal article·2020-07-28

Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant

Yuan Li, Xiangmei Liu, Bo Li, Yufeng Zheng, Yong Han, Da-fu Chen, Kelvin Wai Kwok Yeung, Zhenduo Cui, Yanqin Liang, Zhaoyang Li, Shengli Zhu, Xianbao Wang, Shuilin Wu

ACS Nano· Volume 14· Issue 7
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Source abstract

Abstract

Clinically, methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection inevitably induces the failure of bone implants. Herein, a hydrophilic and viscous hydrogel of poly(vinyl alcohol) modified with chitosan, polydopamine, and NO release donor was formed on a red phosphorus nanofilm deposited on a titanium implant (Ti-RP/PCP/RSNO). Under the irradiation of near-infrared light (NIR), peroxynitrite (•ONOO-) was formed by the reaction between the released NO and superoxide (•O2-) produced by the RP nanofilm. Specifically, we revealed the antibacterial mechanism of the ONOO- against the MRSA biofilm. In addition, osteogenic differentiation was promoted and inflammatory polarization was regulated by the released NO without NIR irradiation through upregulating the expression of Opn and Ocn genes and TNF-α. The MRSA biofilm was synergistically eradicated by •ONOO-, hyperthermia, and •O2- under NIR irradiation as well as the immunoreaction of the M1 polarization. The in vivo results also confirmed the excellent osteogenesis and biofilm eradication by released NO from the RP/PCP/RSNO system under NIR irradiation, indicating the noninvasive tissue reconstruction of MRSA-infected tissues through phototherapy and immunotherapy.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Laser Applications in Dentistry and Medicine · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China

Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China

State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China

State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China

Beijing JiShuiTan Hospital, Beijing Research Institute Orthopaedics & Traumatology, Lab Bone Tissue Engineering, Beijing 100035, China

Department of Orthopaedics & Traumatology, Li KaShing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong 999077, China

Funding

Health and Medical Research Fund · Innovation and Technology Commission · Natural Science Foundation of Hubei Province · National Natural Science Foundation of China

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