DataVXACS NanoPaper
journal article·2015-10-27

Hybrid Mesoporous Silica-Based Drug Carrier Nanostructures with Improved Degradability by Hydroxyapatite

Xiaohong Hao, Xixue Hu, Cuimiao Zhang, Shizhu Chen, Zhenhua Li, Xinjian Yang, Huifang Liu, Guang Jia, Dandan Liu, Kun Ge, Xing-Jie Liang, Jinchao Zhang

ACS Nano· Volume 9· Issue 10
Publisher page
Source abstract

Abstract

Potential bioaccumulation is one of the biggest limitations for silica nanodrug delivery systems in cancer therapy. In this study, a mesoporous silica nanoparticles/hydroxyapatite (MSNs/HAP) hybrid drug carrier, which enhanced the biodegradability of silica, was developed by a one-step method. The morphology and structure of the nanoparticles were characterized by TEM, DLS, FT-IR, XRD, N2 adsorption-desorption isotherms, and XPS, and the drug loading and release behaviors were tested. TEM and ICP-OES results indicate that the degradability of the nanoparticles has been significantly improved by Ca(2+) escape from the skeleton in an acid environment. The MSNs/HAP sample exhibits a higher drug loading content of about 5 times that of MSNs. The biological experiment results show that the MSNs/HAP not only exhibits good biocompatibility and antitumor effect but also greatly reduces the side effects of free DOX. The as-synthesized hybrid nanoparticles may act as a promising drug delivery system due to their good biocompatibility, high drug loading efficiency, pH sensitivity, and excellent biodegradability.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Nanoparticle-Based Drug Delivery · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, People’s Republic of China

CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, People’s Republic of China

Funding

Chinese Academy of Sciences · Education Department, Hebei Province · Natural Science Foundation of Hebei Province · National Center for Research Resources · Ministry of Science and Technology of the People's Republic of China · Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province · State Key Laboratory of Rare Earth Resource Utilization · National Natural Science Foundation of China · China Postdoctoral Science Foundation · Ministry of Education of the People's Republic of China · Hebei Province

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