Graphene-Based Interfaces Do Not Alter Target Nerve Cells
Source abstract
Abstract
Neural-interfaces rely on the ability of electrodes to transduce stimuli into electrical patterns delivered to the brain. In addition to sensitivity to the stimuli, stability in the operating conditions and efficient charge transfer to neurons, the electrodes should not alter the physiological properties of the target tissue. Graphene is emerging as a promising material for neuro-interfacing applications, given its outstanding physico-chemical properties. Here, we use graphene-based substrates (GBSs) to interface neuronal growth. We test our GBSs on brain cell cultures by measuring functional and synaptic integrity of the emerging neuronal networks. We show that GBSs are permissive interfaces, even when uncoated by cell adhesion layers, retaining unaltered neuronal signaling properties, thus being suitable for carbon-based neural prosthetic devices.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Graphene and Nanomaterials Applications · Graphene research and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
International School for Advanced Studies (SISSA/ISAS), Trieste 34136, Italy
Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste 34127, Italy
Life Science Department, University of Trieste, Trieste 34127, Italy
NanoInnovation Laboratory, ELETTRA Synchrotron Light Source, Trieste 34149, Italy
Department of Organic Chemisty, University of Castilla-La Mancha, Ciudad Real 13071, Spain
Cambridge Graphene Centre, University of Cambridge, Cambridge CB3 0FA, United Kingdom
Istituto Italiano di Tecnologia, Graphene Labs, Genova 16163, Italy
Carbon Nanobiotechnology Laboratory, CIC biomaGUNE, Paseo de Miramón 182, 20009 Donostia-San Sebastian, Spain
Basque Foundation for Science, Ikerbasque, Bilbao 48013, Spain
Funding
Engineering and Physical Sciences Research Council · Royal Society · British Academy · European Research Council · Wolfson Foundation · Seventh Framework Programme · Ministero dell'Istruzione, dell'Università e della Ricerca
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