DataVXACS NanoPaper
journal article·2017-04-25

Degradable Semiconducting Oligomer Amphiphile for Ratiometric Photoacoustic Imaging of Hypochlorite

Chao Yin, Xu Zhen, Quli Fan, Wei Huang, Kanyi Pu

ACS Nano· Volume 11· Issue 4
Publisher page
Source abstract

Abstract

Upregulation of highly reactive oxygen species (ROS) such as hypochlorite (ClO – ) is associated with many pathological conditions including cardiovascular diseases, neuron degeneration, lung injury, and cancer. However, real-time imaging of ClO – is limited to the probes generally relying on fluorescence with shallow tissue-penetration depth. We here propose a self-assembly approach to develop activatable and degradable photoacoustic (PA) nanoprobes for in vivo imaging of ClO – . A near-infrared absorbing amphiphilic oligomer is synthesized to undergo degradation in the presence of a specific ROS (ClO – ), which integrates a π-conjugated but ClO – oxidizable backbone with hydrophilic PEG side chains. This molecular architecture allows the oligomer to serve as a degradable nanocarrier to encapsulate the ROS-inert dye and self-assemble into structurally stable nanoparticles through both π–π stacking and hydrophobic interactions. The self-assembled nanoprobe exhibits sensitive and specific ratiometric PA signals toward ClO –, permitting ratiometric PA imaging of ClO – in the tumor of living mice.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China

School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457 Singapore

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China

Funding

Ministry of Science and Technology of the People's Republic of China · Ministry of Education - Singapore · Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Nanyang Technological University · Synergetic Innovation Center for Organic Electronics and Information Displays, Nanjing University of Posts and Telecommunications

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