journal article·2014-06-24Open access

Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles

Zipeng Zhen, Wei Tang, Yen-Jun Chuang, Trever Todd, Weizhong Zhang, Xin Lin, Gang Niu, Gang Liu, Lianchun Wang, Zhengwei Pan, Xiaoyuan Chen, Jin Xie

ACS Nano· Volume 8· Issue 6

Abstract

Delivery of nanoparticle drugs to tumors relies heavily on the enhanced permeability and retention (EPR) effect. While many consider the effect to be equally effective on all tumors, it varies drastically among the tumors' origins, stages, and organs, owing much to differences in vessel leakiness. Suboptimal EPR effect represents a major problem in the translation of nanomedicine to the clinic. In the present study, we introduce a photodynamic therapy (PDT)-based EPR enhancement technology. The method uses RGD-modified ferritin (RFRT) as "smart" carriers that site-specifically deliver (1)O2 to the tumor endothelium. The photodynamic stimulus can cause permeabilized tumor vessels that facilitate extravasation of nanoparticles at the sites. The method has proven to be safe, selective, and effective. Increased tumor uptake was observed with a wide range of nanoparticles by as much as 20.08-fold. It is expected that the methodology can find wide applications in the area of nanomedicine.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, University, of Georgia, Athens, Georgia 30602, United States

Department of Physics, University of Georgia, Athens, Georgia 30602, United States

National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20852, United States

Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China

Department of Biochemistry and Complex Carbohydrate Research Center (CCRC), University of Georgia, Athens, Georgia 30602, United States

Bio-Imaging Research Center (BIRC), University of Georgia, Athens, Georgia 30602, United States

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