journal article·2021-11-23

Environmentally Adaptive Shape-Morphing Microrobots for Localized Cancer Cell Treatment

Chen Xin, Dongdong Jin, Yanlei Hu, Liang Yang, Rui Li, Li Wang, Zhongguo Ren, Dawei Wang, Shengyun Ji, Kai Hu, Deng Pan, Hao Wu, Wulin Zhu, Zuojun Shen, Yucai Wang, Jiawen Li, Li Zhang, Dong Wu, Jiaru Chu

ACS Nano· Volume 15· Issue 11
Publisher page

Abstract

Microrobots have attracted considerable attention due to their extensive applications in microobject manipulation and targeted drug delivery. To realize more complex micro-/nanocargo manipulation (e.g., encapsulation and release) in biological applications, it is highly desirable to endow microrobots with a shape-morphing adaptation to dynamic environments. Here, environmentally adaptive shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rates in a pH-responsive hydrogel. Due to a combination with magnetic propulsion, a shape-morphing microcrab (SMMC) is able to perform targeted microparticle delivery, including gripping, transporting, and releasing by "opening-closing" of a claw. As a proof-of-concept demonstration, a shape-morphing microfish (SMMF) is designed to encapsulate a drug (doxorubicin (DOX)) by closing its mouth in phosphate-buffered saline (PBS, pH ∼ 7.4) and release the drug by opening its mouth in a slightly acidic solution (pH < 7). Furthermore, localized HeLa cell treatment in an artificial vascular network is realized by "opening-closing" of the SMMF mouth. With the continuous optimization of size, motion control, and imaging technology, these magnetic SMMRs will provide ideal platforms for complex microcargo operations and on-demand drug release.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Micro and Nano Robotics · Advanced Materials and Mechanics · Modular Robots and Swarm Intelligence

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China

Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin NT, Hong Kong 999077, China

Institute of Nanotechnology Karlsruhe Institute of Technology (KIT), Karlsruhe 76128, Germany

Intelligent Nanomedicine Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine and Division of Molecular Medicine, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China

Funding

Research Grants Council, University Grants Committee · Ministry of Science and Technology of the People's Republic of China · Youth Innovation Promotion Association of the Chinese Academy of Sciences · Central University Basic Research Fund of China · Innovation and Technology Commission · Croucher Foundation · National Natural Science Foundation of China · Chinese Academy of Sciences · Multi-scale Medical Robotics Center · Major Scientific and Technological Projects in Anhui Province

References (68)

Show source-provided references
1. Alexander R. M. · 2003
2. 10.1126/science.120387410.1126/science.1203874 ↗
3. 10.1126/science.117249010.1126/science.1172490 ↗
4. 10.1038/s41467-021-21986-810.1038/s41467-021-21986-8 ↗
5. 10.1088/0964-1726/25/2/02700110.1088/0964-1726/25/2/027001 ↗
6. 10.1073/pnas.080769810610.1073/pnas.0807698106 ↗
7. 10.1002/anie.20131104710.1002/anie.201311047 ↗
8. 10.1126/sciadv.aau153210.1126/sciadv.aau1532 ↗
9. 10.1002/adma.20130409810.1002/adma.201304098 ↗
10. 10.1126/scirobotics.aax711210.1126/scirobotics.aax7112 ↗
11. 10.1073/pnas.191795211710.1073/pnas.1917952117 ↗
12. 10.1002/marc.20170022410.1002/marc.201700224 ↗
13. 10.1021/acs.nanolett.7b0001510.1021/acs.nanolett.7b00015 ↗
14. 10.1002/adma.20160482510.1002/adma.201604825 ↗
15. 10.1038/s41586-018-0185-010.1038/s41586-018-0185-0 ↗
16. 10.1038/nature2544310.1038/nature25443 ↗
17. 10.1126/scirobotics.aav449410.1126/scirobotics.aav4494 ↗
18. 10.1126/scirobotics.abb982210.1126/scirobotics.abb9822 ↗
19. 10.1038/s41586-019-1713-210.1038/s41586-019-1713-2 ↗
20. 10.1126/scirobotics.abd281310.1126/scirobotics.abd2813 ↗
21. 10.3389/fmech.2017.0000710.3389/fmech.2017.00007 ↗
22. 10.1002/adma.20110381810.1002/adma.201103818 ↗
23. 10.1002/adma.20180822610.1002/adma.201808226 ↗
24. 10.1126/scirobotics.aat048510.1126/scirobotics.aat0485 ↗
25. 10.1021/acsnano.6b0479510.1021/acsnano.6b04795 ↗
26. 10.1126/scirobotics.aam643110.1126/scirobotics.aam6431 ↗
27. 10.1126/scirobotics.aaq115510.1126/scirobotics.aaq1155 ↗
28. 10.1126/scirobotics.aav431710.1126/scirobotics.aav4317 ↗
29. 10.1038/s42256-020-00250-610.1038/s42256-020-00250-6 ↗
30. 10.1002/adma.20200204710.1002/adma.202002047 ↗
31. 10.1021/acsnano.0c0775310.1021/acsnano.0c07753 ↗
32. 10.1126/scirobotics.aat882910.1126/scirobotics.aat8829 ↗
33. 10.1002/anie.20120190210.1002/anie.201201902 ↗
34. 10.1002/adhm.20140025610.1002/adhm.201400256 ↗
35. 10.1021/acsnano.5b0280710.1021/acsnano.5b02807 ↗
36. 10.1002/smll.20130306810.1002/smll.201303068 ↗
37. 10.1021/acs.analchem.7b0520910.1021/acs.analchem.7b05209 ↗
38. 10.1126/sciadv.aau965010.1126/sciadv.aau9650 ↗
39. 10.1038/nnano.2013.5410.1038/nnano.2013.54 ↗
40. 10.1002/adma.20150137210.1002/adma.201501372 ↗
41. 10.1021/acs.nanolett.6b0076810.1021/acs.nanolett.6b00768 ↗
42. 10.1021/acsnano.8b0599710.1021/acsnano.8b05997 ↗
43. 10.1002/adfm.20180410710.1002/adfm.201804107 ↗
44. 10.1021/acsnano.8b0923310.1021/acsnano.8b09233 ↗
45. 10.1002/adfm.20180899210.1002/adfm.201808992 ↗
46. 10.1126/scirobotics.aax704410.1126/scirobotics.aax7044 ↗
47. 10.1126/sciadv.aao386510.1126/sciadv.aao3865 ↗
48. 10.1038/nmat456910.1038/nmat4569 ↗
49. 10.1038/ncomms1554610.1038/ncomms15546 ↗
50. 10.1002/adma.20180684910.1002/adma.201806849 ↗
51. 10.1038/ncomms1226310.1038/ncomms12263 ↗
52. 10.1021/nl201503e10.1021/nl201503e ↗
53. 10.1126/scirobotics.aat444010.1126/scirobotics.aat4440 ↗
54. 10.1038/lsa.2014.1010.1038/lsa.2014.10 ↗
55. 10.37188/lam.2021.01710.37188/lam.2021.017 ↗
56. 10.1002/admt.20200003410.1002/admt.202000034 ↗
57. 10.1016/j.mattod.2020.06.00110.1016/j.mattod.2020.06.001 ↗
58. 10.1016/j.mattod.2019.06.00210.1016/j.mattod.2019.06.002 ↗
59. 10.1038/s41467-018-08175-w10.1038/s41467-018-08175-w ↗
60. 10.1002/anie.20110297510.1002/anie.201102975 ↗
61. 10.1016/j.mattod.2018.07.01710.1016/j.mattod.2018.07.017 ↗
62. 10.37188/lam.2021.00310.37188/lam.2021.003 ↗
63. 10.1126/sciadv.170108410.1126/sciadv.1701084 ↗
64. 10.1002/smll.20130364610.1002/smll.201303646 ↗
65. 10.1038/nmat381910.1038/nmat3819 ↗
66. 10.1038/nrc311010.1038/nrc3110 ↗
67. 10.1126/scirobotics.aaz951910.1126/scirobotics.aaz9519 ↗
68. 10.1126/scirobotics.aax061310.1126/scirobotics.aax0613 ↗