Thermoresponsive in Situ Forming Hydrogel with Sol–Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing

Xu Yan; Wei-Wei Fang; Jingzhe Xue; Tian-Ci Sun; Liang Dong; Zhengbao Zha; Haisheng Qian; Yong-Hong Song; Min Zhang; Xinglong Gong; Yang Lu; Tao He

doi:10.1021/acsnano.9b02845

journal article·2019-09-24

Thermoresponsive in Situ Forming Hydrogel with Sol–Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing

Xu Yan, Wei-Wei Fang, Jingzhe Xue, Tian-Ci Sun, Liang Dong, Zhengbao Zha, Haisheng Qian, Yong-Hong Song, Min Zhang, Xinglong Gong, Yang Lu, Tao He

ACS Nano· Volume 13· Issue 9

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Source abstract

Abstract

An in situ forming hydrogel has emerged as a promising wound dressing recently. As physically cross-linked hydrogels are normally unstable, most in situ forming hydrogels are chemically cross-linked. However, big concerns have remained regarding the slow gelation and the potential toxicity of residual functional groups from cross-linkers or the polymer matrix. Herein, we report a sprayable in situ forming hydrogel composed of poly(N-isopropylacrylamide₁₆₆-co-n-butyl acrylate₉)-poly(ethylene glycol)-poly(N-isopropylacrylamide₁₆₆-co-n-butyl acrylate₉) copolymer (P(NIPAM₁₆₆-co-nBA₉)-PEG-P(NIPAM₁₆₆-co-nBA₉), denoted as PEP) and silver-nanoparticles-decorated reduced graphene oxide nanosheets (Ag@rGO, denoted as AG) in response to skin temperature. This thermoresponsive hydrogel exhibits intriguing sol-gel irreversibility at low temperatures for the stable dressing of a wound, which is attributed to the inorganic/polymeric dual network and abundant coordination interactions between Ag@rGO nanosheets and PNIPAM. The biocompatibility and antibacterial ability against methicillin-resistant Staphylococcus aureus (MRSA) of this PEP-AG hydrogel wound dressing are confirmed in vitro and in vivo, which could transparently promote the healing of a MRSA-infected skin defect.

Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

Polymers Nanomaterials Biomaterials

OpenAlex topics: Wound Healing and Treatments · Hydrogels: synthesis, properties, applications · Antimicrobial agents and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry and Chemical Engineering, Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, Hefei University of Technology, Hefei, Anhui 230009, People’s Republic of China

Department of Chemistry, Hefei National Research Centre for Physical Sciences at the Microscale, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230026, People’s Republic of China

School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, People’s Republic of China

School of Life Science, Anhui University, Hefei, Anhui 230601, People’s Republic of China

Funding

Ministry of Education of the People's Republic of China · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Anhui Province

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