DataVXACS NanoPaper
journal article·2020-02-25

Fluorinated Chitosan To Enhance Transmucosal Delivery of Sonosensitizer-Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation

Guangzhi Li, Shupeng Wang, Dashi Deng, Zhisheng Xiao, Ziliang Dong, Zhiping Wang, Qifang Lei, Shan Gao, Guixiao Huang, Enpu Zhang, Guohua Zeng, Zhong Wen, Song Wu, Zhuang Liu

ACS Nano· Volume 14· Issue 2
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Source abstract

Abstract

Sonodynamic therapy (SDT) is a noninvasive ultrasound-triggered therapeutic strategy for site-specific treatment of tumors with great depth penetration. The design of nano-sonosensitizers suitable for SDT treatment of bladder cancer (BCa) post-intravesical instillation has not yet been reported. Herein, a transmucosal oxygen-self-production SDT nanoplatform is developed to achieve highly efficient SDT against BCa. In this system, fluorinated chitosan (FCS) is synthesized as a highly effective nontoxic transmucosal delivery carrier to assemble with meso-tetra(4-carboxyphenyl)porphine-conjugated catalase (CAT-TCPP). The formed CAT-TCPP/FCS nanoparticles after intravesical instillation into the bladder cavity exhibit excellent transmucosal and intratumoral penetration capacities and could efficiently relieve hypoxia in tumor tissues by the catalase-catalyzed O2 generation from tumor endogenous H2O2 to further improve the therapeutic efficacy of SDT to ablate orthotopic bladder tumors under ultrasound. Our work presents a nano-sonosensitizer formulation with FCS to enhance transmucosal delivery and intratumoral diffusion and CAT to improve tumor oxygenation, promising for instillation-based SDT to treat bladder tumors without the concern of systemic toxicity.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Bladder and Urothelial Cancer Treatments · Obstructive Sleep Apnea Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China

Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, China

Department of Nephrology, The Second Hospital and Center for Renal Diseases, Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China

Department of Urology, The Second Hospital of Lanzhou University, Lanzhou 730030, China

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

Funding

Ministry of Science and Technology of the People's Republic of China · Shenzhen Science and Technology Innovation Commission · National Natural Science Foundation of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Guangdong Medical Science and Technology Research Fund · Special Funds for Strategic Emerging Industries Development in Shenzhen

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