journal article·2020-10-27

Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging

Yuanyuan Yang, Yingjie Yu, Hao Chen, Xiangxi Meng, Wen Ma, Meng Yu, Ziyuan Li, Changhui Li, Haile Liu, Xiaodong Zhang, Haihua Xiao, Zhiqiang Yu

ACS Nano· Volume 14· Issue 10
Publisher page

Abstract

Killing tumor cells with a visualized system is a promising strategy in tumor therapy to achieve minimal side effects and high efficiency. Herein, a theranostic nanomedicine (AuNCs-Pt) is developed based on nanocarrier gold nanoclusters (AuNCs) with bifunctions of both NIR-I/NIR-II imaging and glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II imaging capability on a fatal high-grade serous ovarian cancer (HGSOC) model in the deep abdomen, thus facilitating it to be a promising tool for monitoring platinum transportation. Meanwhile, AuNCs-Pt depletes intracellular glutathione to minimize platinum detoxification, effectively maximizing the chemotherapeutic efficacy of platinum. AuNCs-Pt is used to eradicate the tumor burden in this study on a HGSOC model and a patient-derived tumor xenograft model of hepatocellular carcinoma, suggesting great potential for clinical visualized therapy and platinum drug sensitization.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanocluster Synthesis and Applications · Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, No. 1023, South Shatai Road, Guangzhou 510515, China

Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry, Chinese Academy of Sciences, No. 2, Zhongguancun Road, Beijing 100190, China

Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, No. 15, North Third Ring Road, Beijing 100029, China

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Beijing 100142, China

Department of Biomedical Engineering, College of Engineering, Peking University, No. 5, Yiheyuan Road, Beijing 100871, China

Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University, No. 135, Yaguan Road, Tianjin 300354, China

Funding

Key Research and Development Plan of Hunan Province

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