Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots

Jin Di; Shanshan Yao; Yanqi Ye; Zheng Cui; Jicheng Yu; Tushar K. Ghosh; Yong Zhu; Zhen Gu

doi:10.1021/acsnano.5b03975

journal article·2015-09-22

Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots

Jin Di, Shanshan Yao, Yanqi Ye, Zheng Cui, Jicheng Yu, Tushar K. Ghosh, Yong Zhu, Zhen Gu

ACS Nano· Volume 9· Issue 9

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Source abstract

Abstract

Mechanical force-based stimulus provides a simple and easily accessible manner for spatiotemporally controlled drug delivery. Here we describe a wearable, tensile strain-triggered drug delivery device consisting of a stretchable elastomer and microgel depots containing drug loaded nanoparticles. By applying a tensile strain to the elastomer film, the release of drug from the microdepot is promoted due to the enlarged surface area for diffusion and Poisson's ratio-induced compression on the microdepot. Correspondingly, both sustained drug release by daily body motions and pulsatile release by intentional administration can be conveniently achieved. Our work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. Moreover, polymeric microneedles were further integrated with the stretch-responsive device for transcutaneous delivery of insulin and regulation of blood glucose levels of chemically induced type 1 diabetic mice.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Nanomaterials

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Advancements in Transdermal Drug Delivery · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, United States

Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States

Fiber and Polymer Science Program, Textile Engineering, Chemistry, and Science Department, North Carolina State University, Raleigh, North Carolina 27695, United States

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Funding

Division of Engineering Education and Centers · National Center for Advancing Translational Sciences · American Diabetes Association · Joint Department of Biomedical Engineering · North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill

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