DataVXACS NanoPaper
journal article·2019-06-25

Controlled Co-delivery of Growth Factors through Layer-by-Layer Assembly of Core–Shell Nanofibers for Improving Bone Regeneration

Gu Cheng, Chengcheng Yin, Hu Tu, Shan Jiang, Qun Wang, Xue Zhou, Xin Xing, Congyong Xie, Xiaowen Shi, Yuming Du, Hongbing Deng, Zubing Li

ACS Nano· Volume 13· Issue 6
Publisher page
Source abstract

Abstract

The regeneration of bone tissue is regulated by both osteogenic and angiogenic growth factors which are expressed in a coordinated cascade of events. The aim of this study was to create a dual growth factor-release system that allows for time-controlled release to facilitate bone regeneration. We fabricated core-shell SF/PCL/PVA nanofibrous mats using coaxial electrospinning and layer-by-layer (LBL) techniques, where bone morphogenetic protein 2 (BMP2) was incorporated into the core of the nanofibers and connective tissue growth factor (CTGF) was attached onto the surface. Our study confirmed the sustained release of BMP2 and a rapid release of CTGF. Both in vitro and in vivo experiments demonstrated improvements in bone tissue recovery with the dual-drug release system. In vivo studies showed improvement in bone regeneration by 43% compared with single BMP2 release systems. Time-controlled release enabled by the core-shell nanofiber assembly provides a promising strategy to facilitate bone healing.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China

Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Key Lab of Biomass Resource Chemistry and Environmental Biotechnology, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China

Department of Materials Science and Engineering, Iowa State University, Ames, Iowa 50011, United States

Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Funding

Ministry of Education of the People's Republic of China · Natural Science Foundation of Hubei Province · National Natural Science Foundation of China

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