DataVXACS NanoPaper
journal article·2020-01-28

Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments

Jiong Pan, Ping Hu, Yuedong Guo, Junnian Hao, Dalong Ni, Yingying Xu, Qunqun Bao, Heliang Yao, Chenyang Wei, Qingsheng Wu, Jianlin Shi

ACS Nano· Volume 14· Issue 1
Publisher page
Source abstract

Abstract

Cancer immunotherapy shows promising potential in future cancer treatment but unfortunately is clinically unsatisfactory due to the low therapeutic efficacy and the possible severe immunotoxicity. Here we show a combined magnetic hyperthermia therapy (MHT) and checkpoint blockade immunotherapy for both primary tumor ablation and mimetic metastatic tumor inhibition. Monodispersed, high-performance superparamagnetic CoFe2O4@MnFe2O4 nanoparticles were synthesized and used for effective MHT-induced thermal ablation of primary tumors. Simultaneously, numerous tumor-associated antigens were produced to promote the maturation and activation of dendritic cells (DCs) and cytotoxic T cells for effective immunotherapy of distant mimetic metastatic tumors in a tumor-bearing mice model. The combined MHT and checkpoint blockade immunotherapy demonstrate the great potentials in the fight against both primary and metastatic tumors.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Phagocytosis and Immune Regulation · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemical Science and Engineering, Tongji University, Shanghai 200092, People’s Republic of China

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People’s Republic of China

Chongqing Key Laboratory of Ultrasound Molecular Imaging, Ultrasound Department of the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China

School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, People’s Republic of China

Funding

Natural Science Foundation of Shanghai · Youth Innovation Promotion Association of the Chinese Academy of Sciences · National Natural Science Foundation of China · Shanghai Science and Technology Committee Rising-Star Program · Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures

References (44)

Show source-provided references
1. 10.1038/nrc.2016.2510.1038/nrc.2016.25 ↗
2. 10.1016/j.cell.2017.01.01710.1016/j.cell.2017.01.017 ↗
3. 10.1021/nn506202910.1021/nn5062029 ↗
4. 10.1056/NEJMoa100346610.1056/NEJMoa1003466 ↗
5. 10.1056/NEJMoa120069410.1056/NEJMoa1200694 ↗
6. 10.1158/0008-5472.CAN-11-178210.1158/0008-5472.CAN-11-1782 ↗
7. 10.1158/1078-0432.CCR-16-019010.1158/1078-0432.CCR-16-0190 ↗
8. 10.1158/2326-6066.CIR-16-001310.1158/2326-6066.CIR-16-0013 ↗
9. 10.1172/JCI6731310.1172/JCI67313 ↗
10. 10.1158/0008-5472.CAN-14-125810.1158/0008-5472.CAN-14-1258 ↗
11. 10.1038/nature1429210.1038/nature14292 ↗
12. 10.1056/NEJMoa180100510.1056/NEJMoa1801005 ↗
13. 10.1002/adma.20140299610.1002/adma.201402996 ↗
14. 10.1038/ncomms1319310.1038/ncomms13193 ↗
15. 10.1002/advs.20170089110.1002/advs.201700891 ↗
16. 10.1038/ncomms1249910.1038/ncomms12499 ↗
17. 10.1021/acsnano.7b0071510.1021/acsnano.7b00715 ↗
18. 10.1021/jacs.8b0107210.1021/jacs.8b01072 ↗
19. 10.1063/1.493568810.1063/1.4935688 ↗
20. 10.1016/j.biomaterials.2004.10.01210.1016/j.biomaterials.2004.10.012 ↗
21. 10.1021/acs.nanolett.9b0057910.1021/acs.nanolett.9b00579 ↗
22. 10.1038/nnano.2011.9510.1038/nnano.2011.95 ↗
23. 10.1038/nm73010.1038/nm730 ↗
24. 10.1021/ja038085210.1021/ja0380852 ↗
25. 10.1016/j.biomaterials.2014.07.01910.1016/j.biomaterials.2014.07.019 ↗
26. 10.1021/jp310771p10.1021/jp310771p ↗
27. 10.1063/1.368975110.1063/1.3689751 ↗
28. 10.1021/ar200085c10.1021/ar200085c ↗
29. 10.1038/nm146710.1038/nm1467 ↗
30. 10.1016/j.ultrasmedbio.2004.08.00310.1016/j.ultrasmedbio.2004.08.003 ↗
31. 10.1158/0008-5472.CAN-03-394910.1158/0008-5472.CAN-03-3949 ↗
32. 10.1016/j.biomaterials.2014.08.03610.1016/j.biomaterials.2014.08.036 ↗
33. 10.1073/pnas.19246109910.1073/pnas.192461099 ↗
34. 10.1038/nm86310.1038/nm863 ↗
35. 10.1146/annurev.immunol.24.021605.09073310.1146/annurev.immunol.24.021605.090733 ↗
36. 10.1038/3507724610.1038/35077246 ↗
37. 10.1038/nri184210.1038/nri1842 ↗
38. 10.1038/nature0547910.1038/nature05479 ↗
39. 10.1016/S0167-5699(97)01007-410.1016/S0167-5699(97)01007-4 ↗
40. 10.1634/theoncologist.11-4-39710.1634/theoncologist.11-4-397 ↗
41. Schoenborn J. R. · 2007 · 41
42. 10.1016/j.nano.2016.10.01510.1016/j.nano.2016.10.015 ↗
43. 10.1016/j.jconrel.2018.04.00210.1016/j.jconrel.2018.04.002 ↗
44. 10.1039/C9TB00089E10.1039/C9TB00089E ↗