DataVXACS NanoPaper
journal article·2016-01-26

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

Dongquan Shi, Xingquan Xu, Yanqi Ye, Kai Song, Yixiang Cheng, Jin Di, Quanyin Hu, Jianxin Li, Huangxian Ju, Qing Jiang, Zhen Gu

ACS Nano· Volume 10· Issue 1
Publisher page
Source abstract

Abstract

The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. The previous in vitro study showed that kartogenin also had a chondrogenesis effect on synovium derived mesenchymal stem cells (SMSCs). Herein, we present the effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology. In vivo studies showed its potential role for cell homing, especially for recruiting the host's endogenous cells, including BMSCs and SMSCs, without cell transplantation. Of note, the regenerated tissues were close to the natural hyaline cartilage based on the histological tests, specific markers analysis, and biomechanical tests. This innovative KGN release system makes the chondrogenesis efficient and persistent.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Proteoglycans and glycosaminoglycans research · Silk-based biomaterials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital, Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Zhongshan Road 321, Nanjing 210008, Jiangsu China

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, United States

Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States

Funding

North Carolina State University · National Natural Science Foundation of China

References (24)

Show source-provided references
1. 10.1002/stem.53410.1002/stem.534 ↗
2. 10.1126/science.122245410.1126/science.1222454 ↗
3. 10.1002/art.2731310.1002/art.27313 ↗
4. 10.2741/S37410.2741/S374 ↗
5. 10.1002/jbm.a.3083010.1002/jbm.a.30830 ↗
6. 10.1073/pnas.040735610210.1073/pnas.0407356102 ↗
7. 10.1016/S0142-9612(98)00209-910.1016/S0142-9612(98)00209-9 ↗
8. 10.1126/science.121515710.1126/science.1215157 ↗
9. 10.1359/JBMR.05051610.1359/JBMR.050516 ↗
10. 10.1038/onc.2008.19510.1038/onc.2008.195 ↗
11. 10.1073/pnas.150540511210.1073/pnas.1505405112 ↗
12. 10.1038/ncomms436410.1038/ncomms4364 ↗
13. 10.1021/acsnano.5b0397510.1021/acsnano.5b03975 ↗
14. 10.1021/nn401617u10.1021/nn401617u ↗
15. 10.1053/joca.2002.080110.1053/joca.2002.0801 ↗
16. 10.1016/j.joca.2013.03.01510.1016/j.joca.2013.03.015 ↗
17. 10.1073/pnas.132174411110.1073/pnas.1321744111 ↗
18. 10.1002/art.2121210.1002/art.21212 ↗
19. Shi M. · J. Immunol. · 1998 · 161 · 675110.4049/jimmunol.161.12.6751 ↗
20. 10.1128/MCB.20.23.8783-8792.200010.1128/MCB.20.23.8783-8792.2000 ↗
21. 10.1073/pnas.18030959710.1073/pnas.180309597 ↗
22. 10.1371/journal.pone.005925010.1371/journal.pone.0059250 ↗
23. 10.1021/acsnano.5b0356910.1021/acsnano.5b03569 ↗
24. 10.1002/adfm.20130322210.1002/adfm.201303222 ↗