Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells
Source abstract
Abstract
Tumor reinitiating cancer stem-like cells are responsible for cancer recurrence associated with conventional chemotherapy. We developed a doxorubicin-encapsulated polymeric nanoparticle surface-decorated with chitosan that can specifically target the CD44 receptors of these cells. This nanoparticle system was engineered to release the doxorubicin in acidic environments, which occurs when the nanoparticles are localized in the acidic tumor microenvironment and when they are internalized and localized in the cellular endosomes/lysosomes. This nanoparticle design strategy increases the cytotoxicity of the doxorubicin by six times in comparison to the use of free doxorubicin for eliminating CD44(+) cancer stem-like cells residing in 3D mammary tumor spheroids (i.e., mammospheres). We further show these nanoparticles reduced the size of tumors in an orthotopic xenograft tumor model with no evident systemic toxicity. The development of nanoparticle system to target cancer stem-like cells with low systemic toxicity provides a new treatment arsenal for improving the survival of cancer patients.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cancer Cells and Metastasis · Nanoparticle-Based Drug Delivery · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio 43210, United States
Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, United States
Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States
Division of Hematology, The Ohio State University, Columbus, Ohio 43210, United States
Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, Wisconsin 53202, United States
Centre for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China
Division of Genitourinary Pathology, The Ohio State University, Columbus, Ohio 43210, United States
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States
Funding
American Cancer Society
References (58)
Show source-provided references
1. Jordan C. T. · N. Engl. J. Med. · 2006 · 355 · 125310.1056/NEJMra061808 ↗
2. Frank N. Y. · J. Clin. Invest. · 2010 · 120 · 4110.1172/JCI41004 ↗
3. Visvader J. E. · Nat. Rev. Cancer · 2008 · 8 · 75510.1038/nrc2499 ↗
4. Ponta H. · Nat. Rev. Mol. Cell Biol. · 2003 · 4 · 3310.1038/nrm1004 ↗
5. Louderbough J. M. V. · Mol. Cancer Res. · 2011 · 9 · 157310.1158/1541-7786.MCR-11-0156 ↗
6. Zhou S. · Nat. Med. · 2001 · 7 · 102810.1038/nm0901-1028 ↗
7. Dean M. · Nat. Rev. Cancer · 2005 · 5 · 27510.1038/nrc1590 ↗
8. Hermann P. C. · Cell Stem Cell · 2007 · 1 · 31310.1016/j.stem.2007.06.002 ↗
9. Al-Hajj M. · Proc. Natl. Acad. Sci. U.S.A. · 2003 · 100 · 398310.1073/pnas.0530291100 ↗
10. Kruger J. A. · Blood · 2006 · 108 · 390610.1182/blood-2006-05-024687 ↗
11. Bandyopadhyay A. · PLoS One · 2010 · 5 · e1036510.1371/journal.pone.0010365 ↗
12. Wang X. · ACS Nano · 2014 · 8 · 1215110.1021/nn503491e ↗
13. Wang F. · ACS Nano · 2011 · 5 · 367910.1021/nn200007z ↗
14. Gao Y. · ACS Nano · 2011 · 5 · 978810.1021/nn2033105 ↗
15. Kabanov A. V. · Adv. Drug Delivery Rev. · 2002 · 54 · 75910.1016/S0169-409X(02)00047-9 ↗
16. Bapat S. A. · Reproduction · 2010 · 140 · 3310.1530/REP-09-0389 ↗
17. Naumov G. N. · J. Natl. Cancer Inst. · 2006 · 98 · 31610.1093/jnci/djj068 ↗
18. Chuthapisith S. · Surg. Oncol. · 2010 · 19 · 2710.1016/j.suronc.2009.01.004 ↗
19. Marotta L. L. · J. Clin. Invest. · 2011 · 121 · 272310.1172/JCI44745 ↗
20. Korkaya H. · J. Clin. Invest. · 2011 · 121 · 380410.1172/JCI57099 ↗
21. Chin A. R. · Mol. Cell. Endocrinol. · 2013 · 382 · 59810.1016/j.mce.2013.03.024 ↗
22. Du J.-Z. · J. Am. Chem. Soc. · 2011 · 133 · 1756010.1021/ja207150n ↗
23. Yao H. J. · Biomaterials · 2014 · 920810.1016/j.biomaterials.2014.07.033 ↗
24. Burke A. R. · Biomaterials · 2012 · 33 · 296110.1016/j.biomaterials.2011.12.052 ↗
25. Wang C. H. · Nanomedicine · 2011 · 7 · 6910.1016/j.nano.2010.06.010 ↗
26. Wang D. · Biomaterials · 2013 · 34 · 766210.1016/j.biomaterials.2013.06.042 ↗
27. Zhang W. · ACS Nano · 2010 · 4 · 674710.1021/nn101617n ↗
28. Rao W. · Acta Biomater. · 2014 · 10 · 83110.1016/j.actbio.2013.10.020 ↗
29. Riva R. · Adv. Polym. Sci. · 2011 · 244 · 1910.1007/12_2011_137 ↗
30. Senel S. · Adv. Drug Delivery Rev. · 2004 · 56 · 146710.1016/j.addr.2004.02.007 ↗
31. Ramya R. · J. Biomater. Tissue Eng. · 2012 · 2 · 10010.1166/jbt.2012.1030 ↗
32. Bowman K. · Int. J. Nanomed. · 2006 · 1 · 11710.2147/nano.2006.1.2.117 ↗
33. Yomota C. · Yakugaku Zasshi · 1990 · 110 · 44210.1248/yakushi1947.110.6_442 ↗
34. Kulish E. I. · Polym. Sci., Ser. B · 2008 · 50 · 17510.1134/S156009040807004X ↗
35. Cabral H. · Nat. Nanotechnol. · 2011 · 6 · 81510.1038/nnano.2011.166 ↗
36. Farokhzad O. C. · ACS Nano · 2009 · 3 · 1610.1021/nn900002m ↗
37. Fang J. · Adv. Drug Delivery Rev. · 2011 · 63 · 13610.1016/j.addr.2010.04.009 ↗
38. Chauhan V. P. · Nat. Nanotechnol. · 2012 · 7 · 38310.1038/nnano.2012.45 ↗
39. Sykes E. A. · ACS Nano · 2014 · 8 · 569610.1021/nn500299p ↗
40. Guttilla I. K. · Breast Cancer Res. Treat. · 2012 · 132 · 7510.1007/s10549-011-1534-y ↗
41. Harrison H. · Breast Cancer Res. · 2013 · 15 · R2110.1186/bcr3396 ↗
42. Shipitsin M. · Cancer Cell · 2007 · 11 · 25910.1016/j.ccr.2007.01.013 ↗
43. Lorico A. · J. Oncol. · 2011 · 2011 · 13503910.1155/2011/135039 ↗
44. Wright M. H. · Breast Cancer Res. · 2008 · 10 · R1010.1186/bcr1855 ↗
45. Shackleton M. · Nature · 2006 · 439 · 8410.1038/nature04372 ↗
46. Molyneux G. · Cell Stem Cell · 2010 · 7 · 40310.1016/j.stem.2010.07.010 ↗
47. Rao W. · Biomaterials · 2014 · 35 · 776210.1016/j.biomaterials.2014.06.011 ↗
48. Vrignaud S. · Biomaterials · 2011 · 32 · 859310.1016/j.biomaterials.2011.07.057 ↗
49. Weigel P. H. · J. Biol. Chem. · 1981 · 256 · 261510.1016/S0021-9258(19)69656-0 ↗
50. El-Dakdouki M. H. · Nanoscale · 2013 · 5 · 390410.1039/c3nr90022c ↗
51. Mo R. · Nat. Commun. · 2014 · 5 · 336410.1038/ncomms4364 ↗
52. Banerji S. · Nat. Struct. Mol. Biol. · 2007 · 14 · 23410.1038/nsmb1201 ↗
53. Naor D. · Crit. Rev. Clin. Lab. Sci. · 2002 · 39 · 52710.1080/10408360290795574 ↗
54. Sleeman J. P. · J. Biol. Chem. · 1997 · 272 · 3183710.1074/jbc.272.50.31837 ↗
55. Wang S. · Proc. Natl. Acad. Sci. U.S.A. · 2006 · 103 · 148010.1073/pnas.0510652103 ↗
56. Pellacani D. · Adv. Exp. Med. Biol. · 2013 · 777 · 16710.1007/978-1-4614-5894-4_11 ↗
57. Dontu G. · Gene Dev. · 2003 · 17 · 125310.1101/gad.1061803 ↗
58. Zhang W. · J. Mater. Chem. B · 2013 · 1 · 100210.1039/C2TB00058J ↗