DataVXACS NanoPaper
journal article·2019-04-23

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

Guang Yang, Qian Chen, Di Wen, Zhaowei Chen, Jinqiang Wang, Guojun Chen, Zejun Wang, Xudong Zhang, Yuqi Zhang, Quanyin Hu, Liang Zhang, Zhen Gu

ACS Nano· Volume 13· Issue 4
Publisher page
Source abstract

Abstract

Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Hair Growth and Disorders · Advancements in Transdermal Drug Delivery · Skin and Cellular Biology Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering, University of California, Los Angeles, California 90095, United States

California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, California 90095, United States

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, United States

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People’s Republic of China

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, People’s Republic of China

Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, People’s Republic of China

Shanghai Institutes for Biological Sciences−Changzheng Hospital Joint Center for Translational Research, Institutes for Translational Research (CAS-SMMU), Shanghai, 200433, People’s Republic of China

Funding

North Carolina State University · Chinese Academy of Sciences · University of California, Los Angeles · University of North Carolina at Chapel Hill

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