DataVXACS NanoPaper
journal article·2019-10-22

Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma

Ruijuan Yan, Si Sun, Jiang Yang, Wei Long, Junying Wang, Xiaoyu Mu, Qifeng Li, Wenting Hao, Shaofang Zhang, Haile Liu, Yalong Gao, Lufei Ouyang, Junchi Chen, Shuangjie Liu, Xiao-Dong Zhang, Dong Ming

ACS Nano· Volume 13· Issue 10
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Source abstract

Abstract

Neurotrauma is one of the most serious traumatic injuries, which can induce an excess amount of reactive oxygen and nitrogen species (RONS) around the wound, triggering a series of biochemical responses and neuroinflammation. Traditional antioxidant-based bandages can effectively decrease infection via preventing oxidative stress, but its effectiveness is limited to a short period of time due to the rapid loss of electron-donating ability. Herein, we developed a nanozyme-based bandage using single-atom Pt/CeO2 with a persistent catalytic activity for noninvasive treatment of neurotrauma. Single-atom Pt induced the lattice expansion and preferred distribution on (111) facets of CeO2, enormously increasing the endogenous catalytic activity. Pt/CeO2 showed a 2–10 times higher scavenging activity against RONS as well as 3–10 times higher multienzyme activities compared to CeO2 clusters. The single-atom Pt/CeO2 retained the long-lasting catalytic activity for up to a month without obvious decay due to enhanced electron donation through the Mars–van Krevelen reaction. In vivo studies disclosed that the nanozyme-based bandage at the single-atom level can significantly improve the wound healing of neurotrauma and reduce neuroinflammation.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Number 238, Baidi Road, Tianjin 300192, China

Department of Neurosurgery and Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Tianjin Medical University General Hospital, Tianjin 300052, China

Tianjin International Joint Reserch Center for Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China

Funding

Natural Science Foundation of Tianjin City · National Natural Science Foundation of China · Innovation Foundation, Tianjin University

References (59)

Show source-provided references
1. 10.1038/nrdp.2016.8410.1038/nrdp.2016.84 ↗
2. 10.1001/jamaneurol.2014.355810.1001/jamaneurol.2014.3558 ↗
3. 10.1038/nrneurol.2013.3310.1038/nrneurol.2013.33 ↗
4. 10.2174/09298670878349733710.2174/092986708783497337 ↗
5. 10.1038/nrn203810.1038/nrn2038 ↗
6. 10.1126/science.aaf626010.1126/science.aaf6260 ↗
7. 10.1038/nrneurol.2014.1510.1038/nrneurol.2014.15 ↗
8. 10.1089/wound.2012.040110.1089/wound.2012.0401 ↗
9. 10.1038/nnano.2012.9010.1038/nnano.2012.90 ↗
10. 10.1038/nnano.2007.26010.1038/nnano.2007.260 ↗
11. 10.1002/ange.20180068110.1002/ange.201800681 ↗
12. 10.1021/acs.chemrev.8b0067210.1021/acs.chemrev.8b00672 ↗
13. 10.1007/s12274-017-1426-510.1007/s12274-017-1426-5 ↗
14. 10.1002/anie.20171246910.1002/anie.201712469 ↗
15. 10.1021/acs.chemrev.8b0062610.1021/acs.chemrev.8b00626 ↗
16. 10.1002/adma.20180536810.1002/adma.201805368 ↗
17. 10.1002/anie.20170857310.1002/anie.201708573 ↗
18. 10.1002/anie.20160086810.1002/anie.201600868 ↗
19. 10.1021/acsnano.7b0749610.1021/acsnano.7b07496 ↗
20. 10.1002/anie.20181377110.1002/anie.201813771 ↗
21. 10.1039/C8CS00457A10.1039/C8CS00457A ↗
22. 10.1021/jacs.6b1293210.1021/jacs.6b12932 ↗
23. 10.1002/adma.20190288510.1002/adma.201902885 ↗
24. 10.1002/anie.20046064910.1002/anie.200460649 ↗
25. 10.1039/c3cs35486e10.1039/c3cs35486e ↗
26. 10.1021/ar100059g10.1021/ar100059g ↗
27. 10.1021/acsnano.5b0426110.1021/acsnano.5b04261 ↗
28. 10.1039/C7CS00471K10.1039/C7CS00471K ↗
29. 10.1021/jacs.7b0060110.1021/jacs.7b00601 ↗
30. 10.1021/acsnano.8b0537010.1021/acsnano.8b05370 ↗
31. 10.1038/s41570-018-0010-110.1038/s41570-018-0010-1 ↗
32. 10.1021/acs.chemrev.8b0050110.1021/acs.chemrev.8b00501 ↗
33. 10.1002/anie.20181399410.1002/anie.201813994 ↗
34. 10.1002/ange.20190564510.1002/ange.201905645 ↗
35. 10.1038/nchem.109510.1038/nchem.1095 ↗
36. 10.1002/anie.20150302210.1002/anie.201503022 ↗
37. 10.1002/anie.20141039810.1002/anie.201410398 ↗
38. 10.1021/acsnano.8b0199410.1021/acsnano.8b01994 ↗
39. 10.1021/nn403743b10.1021/nn403743b ↗
40. 10.1002/anie.20120378010.1002/anie.201203780 ↗
41. 10.1021/acsnano.5b0804510.1021/acsnano.5b08045 ↗
42. 10.1038/ncomms1080110.1038/ncomms10801 ↗
43. 10.1126/science.aaf880010.1126/science.aaf8800 ↗
44. 10.1126/science.aao210910.1126/science.aao2109 ↗
45. 10.1021/acscatal.6b0268510.1021/acscatal.6b02685 ↗
46. 10.1002/anie.20140960110.1002/anie.201409601 ↗
47. 10.1021/ja302070k10.1021/ja302070k ↗
48. 10.1021/acs.jpcc.8b0581510.1021/acs.jpcc.8b05815 ↗
49. 10.1038/s41467-018-03903-810.1038/s41467-018-03903-8 ↗
50. 10.1021/acsnano.8b0804510.1021/acsnano.8b08045 ↗
51. 10.1021/acsnano.7b0774610.1021/acsnano.7b07746 ↗
52. 10.1021/acs.jpcc.7b0031310.1021/acs.jpcc.7b00313 ↗
53. 10.1021/acs.nanolett.8b0370910.1021/acs.nanolett.8b03709 ↗
54. 10.1021/acsnano.9b0045710.1021/acsnano.9b00457 ↗
55. 10.1038/s41467-018-05798-x10.1038/s41467-018-05798-x ↗
56. 10.1038/ncomms630110.1038/ncomms6301 ↗
57. 10.1039/C7SC05476A10.1039/C7SC05476A ↗
58. 10.1038/527S218a10.1038/527S218a ↗
59. 10.1002/adma.20100276310.1002/adma.201002763 ↗