DataVXACS NanoPaper
journal article·2014-02-25

ZnO Nanowire Arrays on 3D Hierachical Graphene Foam: Biomarker Detection of Parkinson’s Disease

Hong Yan Yue, Shuo Huang, Jian Chang, Chaejeong Heo, Fei Yao, Subash Adhikari, Fethullah Gunes, Li Chun Liu, Tae Hoon Lee, Eung Seok Oh, Bing Li, Jian Jiao Zhang, Ta Quang Huy, Nguyen Van Luan, Young Hee Lee

ACS Nano· Volume 8· Issue 2
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Source abstract

Abstract

We report that vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimized ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson's disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Conducting polymers and applications · Electrochemical sensors and biosensors · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centre for Integrated Nanostructure Physics, Institute for Basic Science, Sungkyunkwan University, Suwon 440-746, Republic of Korea

Department of Energy Science, Department of Physics, Sungkyunkwan University, Suwon 440-746, Republic of Korea

School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People’s Republic of China

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People’s Republic of China

Centre for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon 440-746, Republic of Korea

Department of Neurology, Chungnam National University Hospital, School of Medicine, Chungnam National University, Daejeon 103-721, Republic of Korea

References (30)

Show source-provided references
1. Novoselov K. S. · Nature · 2012 · 490 · 19210.1038/nature11458 ↗
2. Chen S. · ACS Nano · 2011 · 5 · 132110.1021/nn103028d ↗
3. Liu Y. · Chem. Soc. Rev. · 2012 · 41 · 228310.1039/C1CS15270J ↗
4. Chen Z. · Nat. Mater. · 2011 · 10 · 42410.1038/nmat3001 ↗
5. Li N. · Proc. Natl. Acad. Sci. U.S.A. · 2012 · 109 · 1736010.1073/pnas.1210072109 ↗
6. Kenry · Prog. Mater. Sci. · 2013 · 58 · 70510.1016/j.pmatsci.2013.01.001 ↗
7. Wang Z. L. · Science · 2006 · 312 · 24210.1126/science.1124005 ↗
8. Law M. · Nat. Mater. · 2005 · 4 · 45510.1038/nmat1387 ↗
9. Yoon S. M. · ACS Nano · 2012 · 6 · 680310.1021/nn301546z ↗
10. Hass B. R. · Transl. Neurodegener. · 2012 · 1 · 1110.1186/2047-9158-1-11 ↗
11. Sheng Z. H. · Biosens. Bioelectron. · 2012 · 34 · 12510.1016/j.bios.2012.01.030 ↗
12. Sun C. L. · ACS Nano · 2011 · 5 · 778810.1021/nn2015908 ↗
13. Thompson J. · 2013
14. Sekli-Belaidi F. · J. Electroanal. Chem. · 2010 · 647 · 15910.1016/j.jelechem.2010.06.007 ↗
15. Wu L. · Biosens. Bioelectron. · 2012 · 34 · 5710.1016/j.bios.2012.01.007 ↗
16. Gochman N. · Clin. Chem. · 1971 · 17 · 115410.1093/clinchem/17.12.1154 ↗
17. Yu J. · Lab Chip · 2011 · 11 · 128610.1039/c0lc00524j ↗
18. Sansuk S. · Anal. Chem. · 2013 · 85 · 16310.1021/ac3023586 ↗
19. Bryan T. · Chem. Sci. · 2012 · 3 · 346810.1039/c2sc21221h ↗
20. Lang X. Y. · Nat. Commun. · 2013 · 4 · 216910.1038/ncomms3169 ↗
21. Chen Q. · Appl. Phys. Lett. · 2010 · 96 · 07211
22. Hadi M. · Anal. Chim. Acta · 2012 · 721 · 5510.1016/j.aca.2012.01.051 ↗
23. Yadav R. A. · Spectrochim. Acta · 2011 · 84 · 610.1016/j.saa.2011.07.043 ↗
24. Mohammad-Shiri M. · Int. J. Electrochem. Sci. · 2011 · 6 · 31710.1016/S1452-3981(23)14998-4 ↗
25. Masoud M. S. · Spectrochim. Acta, Part A · 2012 · 90 · 9310.1016/j.saa.2012.01.028 ↗
26. Cipriani S. · Biomarkers Med. · 2010 · 4 · 70110.2217/bmm.10.94 ↗
27. Schwarzschild M. A. · Arch. Neurol. · 2008 · 65 · 71610.1001/archneur.2008.65.6.nct70003 ↗
28. Kish S. J. · N. Engl. J. Med. · 1988 · 318 · 87610.1056/NEJM198804073181402 ↗
29. Atta N. F. · Anal. Biochem. · 2010 · 400 · 7810.1016/j.ab.2010.01.001 ↗
30. Park H. · Nano Lett. · 2013 · 13 · 23310.1021/nl303920b ↗