DataVXACS NanoPaper
journal article·2019-01-22

Multifunctional Two-Dimensional Core–Shell MXene@Gold Nanocomposites for Enhanced Photo–Radio Combined Therapy in the Second Biological Window

Wantao Tang, Ziliang Dong, Rui Zhang, Xuan Yi, Kai Yang, Meilin Jin, Chao Yuan, Zhidong Xiao, Zhuang Liu, Liang Cheng

ACS Nano· Volume 13· Issue 1
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Source abstract

Abstract

Multifunctional nanoplatforms with special advantages in the diagnosis and treatment of cancer have been widely explored in nanomedicine. Herein, we synthesize two-dimensional core–shell nanocomposites (Ti3C2@Au) via a seed-growth method starting from the titanium carbide (Ti3C2) nanosheets, a classical type of MXene nanostructure. After growing gold on the surface of Ti3C2 nanosheets, the stability and biocompatibility of the nanocomposites are greatly improved by the thiol modification. Also importantly, the optical absorption in the near-infrared region is enhanced. Utilizing the ability of the high optical absorbance and strong X-ray attenuation, the synthesized Ti3C2@Au nanocomposites are used for photoacoustic and computed tomography dual-modal imaging. Importantly, the mild photothermal effect of the Ti3C2@Au nanocomposites could improve the tumor oxygenation, which significantly enhances the radiotherapy. No obvious long-term toxicity of the nanocomposites is found at the injected dose. This work highlights the promise of special properties of MXene-based multifunctional nanostructures for cancer theranostics.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: MXene and MAX Phase Materials · Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University Suzhou 215123, China

School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu 215123, China

Funding

Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University · Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University · Priority Academic Program Development of Jiangsu Higher Education Institutions

References (49)

Show source-provided references
1. 10.1038/nchembio.171210.1038/nchembio.1712 ↗
2. 10.1038/nnano.2007.38710.1038/nnano.2007.387 ↗
3. 10.1016/j.ccell.2015.03.00110.1016/j.ccell.2015.03.001 ↗
4. 10.1038/nrc306410.1038/nrc3064 ↗
5. 10.1038/ncomms436410.1038/ncomms4364 ↗
6. 10.1038/nrc.2017.1710.1038/nrc.2017.17 ↗
7. 10.1021/cr400532z10.1021/cr400532z ↗
8. 10.1021/acs.chemrev.6b0052510.1021/acs.chemrev.6b00525 ↗
9. 10.1021/acs.chemrev.7b0025810.1021/acs.chemrev.7b00258 ↗
10. 10.1002/adma.20170674710.1002/adma.201706747 ↗
11. 10.1039/C2CS35342C10.1039/C2CS35342C ↗
12. 10.1021/acs.chemrev.5b0014810.1021/acs.chemrev.5b00148 ↗
13. 10.1002/adma.20110129510.1002/adma.201101295 ↗
14. 10.1021/ja057254a10.1021/ja057254a ↗
15. 10.1039/b517615h10.1039/b517615h ↗
16. 10.1002/adma.20130449710.1002/adma.201304497 ↗
17. 10.1021/nn506137n10.1021/nn506137n ↗
18. 10.1002/adma.20140563410.1002/adma.201405634 ↗
19. 10.1002/adfm.20130104510.1002/adfm.201301045 ↗
20. 10.1038/ncomms454610.1038/ncomms4546 ↗
21. 10.1021/jacs.6b0519210.1021/jacs.6b05192 ↗
22. 10.1002/adtp.20180005710.1002/adtp.201800057 ↗
23. 10.1002/adma.20170598010.1002/adma.201705980 ↗
24. 10.1021/jacs.8b0036810.1021/jacs.8b00368 ↗
25. 10.1021/acsami.8b1567810.1021/acsami.8b15678 ↗
26. 10.1002/adma.20140070310.1002/adma.201400703 ↗
27. 10.1038/nmat447610.1038/nmat4476 ↗
28. 10.1039/C7NR07927C10.1039/C7NR07927C ↗
29. 10.1002/adma.20180259110.1002/adma.201802591 ↗
30. 10.1038/natrevmats.2016.9810.1038/natrevmats.2016.98 ↗
31. 10.1002/adma.20110230610.1002/adma.201102306 ↗
32. 10.1038/nmat438610.1038/nmat4386 ↗
33. 10.1007/s12274-018-2075-z10.1007/s12274-018-2075-z ↗
34. 10.1002/anie.20160664310.1002/anie.201606643 ↗
35. 10.1021/acs.nanolett.6b0433910.1021/acs.nanolett.6b04339 ↗
36. 10.1002/adhm.20170139410.1002/adhm.201701394 ↗
37. 10.1021/acsami.7b1342110.1021/acsami.7b13421 ↗
38. 10.1021/acsnano.7b0724110.1021/acsnano.7b07241 ↗
39. 10.1021/jacs.7b0781810.1021/jacs.7b07818 ↗
40. 10.1021/acs.chemmater.7b0244110.1021/acs.chemmater.7b02441 ↗
41. 10.1038/srep3204910.1038/srep32049 ↗
42. 10.1002/adma.20130413810.1002/adma.201304138 ↗
43. 10.1002/adma.20160484710.1002/adma.201604847 ↗
44. 10.1002/anie.20110144710.1002/anie.201101447 ↗
45. 10.1038/nmat378010.1038/nmat3780 ↗
46. 10.1021/acsnano.5b0460610.1021/acsnano.5b04606 ↗
47. 10.1002/adfm.20150481010.1002/adfm.201504810 ↗
48. 10.1021/acsnano.7b0385710.1021/acsnano.7b03857 ↗
49. 10.1002/ange.20170712810.1002/ange.201707128 ↗