DataVXACS NanoPaper
journal article·2015-07-28Open access

Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation

Attilio Marino, Satoshi Arai, Yanyan Hou, Edoardo Sinibaldi, Mario Pellegrino, Young-Tae Chang, Barbara Mazzolai, Virgilio Mattoli, Madoka Suzuki, Gianni Ciofani

ACS Nano· Volume 9· Issue 7
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Source abstract

Abstract

Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Neuroscience and Neural Engineering · Planarian Biology and Electrostimulation · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Micro-BioRobotics, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy

The Biorobotics Institute, Scuola Superiore Sant’Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy

WASEDA Bioscience Research Institute in Singapore (WABIOS), Biopolis Way 11, #05-02 Helios, 138667 Singapore

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, University of Pisa, Via Savi 10, 56126 Pisa, Italy

Department of Chemistry, National University of Singapore, MedChem Program of Life Sciences Institute, National University of Singapore, 3 Science Drive 3, 117543 Singapore

Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Biopolis, 138667 Singapore

Organization for University Research Initiatives, Waseda University, #304, Block 120-4, 513 Waseda-Tsurumaki-Cho, Shinjuku-Ku, 162-0041 Tokyo, Japan

Funding

Ministero della Salute · Japan Society for the Promotion of Science

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