Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy
Source abstract
Abstract
Multifunctional nanomaterials with integrated diagnostic and therapeutic functions, combination therapy to enhance treatment efficacy, as well as low toxicity have drawn tremendous attentions. Herein, we report a multifunctional theranostic agent based on peptide (LyP-1)-labeled ultrasmall semimetal nanoparticles of bismuth (Bi-LyP-1 NPs). Ultrasmall Bi NPs (3.6 nm) were facilely synthesized using oleylamine as the reducing agent and exhibited a higher tumor accumulation after being conjugated with the tumor-homing peptide LyP-1. The abilities to absorb both ionizing radiation and the second near-infrared (NIR-II) window laser radiation ensured that Bi-LyP-1 NPs are capable of dual-modal computed tomography/photoacoustic imaging and efficient synergistic NIR-II photothermal/radiotherapy of tumors. Moreover, Bi-LyP-1 NPs could be rapidly cleared from mice through both renal and fecal clearance and almost completely cleared after 30 days. Such multifunctional nanoparticles as efficient cancer theranostic agents, coupled with fast clearance and low toxicity, shed light on the future use of semimetal nanoparticles for biomedicine.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China
School of Radiation Medicine and Protection (SRMP) and School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, People’s Republic of China
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States
Funding
Natural Science Foundation of Jiangsu Province · National Institute of Biomedical Imaging and Bioengineering · National Natural Science Foundation of China · Medicine and Engineering Cross Research Foundation, Shanghai Jiao Tong University · Priority Academic Program Development of Jiangsu Higher Education Institutions · Science and Technology Committee of Shanghai Municipality
References (74)
Show source-provided references
1. 10.1021/ar200022e10.1021/ar200022e ↗
2. 10.1021/ar200085c10.1021/ar200085c ↗
3. 10.1038/nrc156610.1038/nrc1566 ↗
4. 10.1021/cr300213b10.1021/cr300213b ↗
5. 10.1021/ar200019c10.1021/ar200019c ↗
6. 10.7150/thno.869810.7150/thno.8698 ↗
7. 10.1002/adma.20110014010.1002/adma.201100140 ↗
8. 10.1021/ar200018x10.1021/ar200018x ↗
9. 10.1021/ar200017e10.1021/ar200017e ↗
10. 10.1002/adfm.20120331710.1002/adfm.201203317 ↗
11. 10.1021/nl070345g10.1021/nl070345g ↗
12. 10.1016/j.nano.2005.10.00610.1016/j.nano.2005.10.006 ↗
13. 10.1007/s11434-014-0700-010.1007/s11434-014-0700-0 ↗
14. 10.1038/nbt134010.1038/nbt1340 ↗
15. 10.1021/ar200031510.1021/ar2000315 ↗
16. 10.1002/anie.20110410410.1002/anie.201104104 ↗
17. 10.1038/nnano.2008.3010.1038/nnano.2008.30 ↗
18. 10.1002/adma.20150142010.1002/adma.201501420 ↗
19. 10.1038/nnano.2009.23110.1038/nnano.2009.231 ↗
20. 10.1002/adma.20150032310.1002/adma.201500323 ↗
21. 10.1002/adma.20140425710.1002/adma.201404257 ↗
22. 10.1002/ange.20140847210.1002/ange.201408472 ↗
23. 10.1016/j.radonc.2008.05.01510.1016/j.radonc.2008.05.015 ↗
24. 10.1002/adma.20140086610.1002/adma.201400866 ↗
25. 10.1016/j.ijrobp.2010.08.04410.1016/j.ijrobp.2010.08.044 ↗
26. 10.1371/journal.pone.006242510.1371/journal.pone.0062425 ↗
27. 10.1002/adfm.20130231210.1002/adfm.201302312 ↗
28. 10.1021/ja404985w10.1021/ja404985w ↗
29. 10.1002/adma.20160211110.1002/adma.201602111 ↗
30. 10.1021/nn405701q10.1021/nn405701q ↗
31. 10.1002/adma.20150300610.1002/adma.201503006 ↗
32. 10.1007/s10555-007-9056-010.1007/s10555-007-9056-0 ↗
33. 10.1016/j.clon.2007.03.01510.1016/j.clon.2007.03.015 ↗
34. 10.1002/adma.20160616710.1002/adma.201606167 ↗
35. 10.1021/nn103415x10.1021/nn103415x ↗
36. 10.1016/j.biomaterials.2015.01.02810.1016/j.biomaterials.2015.01.028 ↗
37. 10.1038/nrc367210.1038/nrc3672 ↗
38. 10.1002/adhm.20130054910.1002/adhm.201300549 ↗
39. 10.1002/smll.20120253810.1002/smll.201202538 ↗
40. 10.1088/0022-3727/38/15/00410.1088/0022-3727/38/15/004 ↗
41. 10.1021/nn506137n10.1021/nn506137n ↗
42. 10.1002/adma.20120221110.1002/adma.201202211 ↗
43. 10.1002/adma.20130189010.1002/adma.201301890 ↗
44. 10.1038/nmat298610.1038/nmat2986 ↗
45. 10.1021/ja412735p10.1021/ja412735p ↗
46. 10.7150/thno.1138710.7150/thno.11387 ↗
47. 10.1039/C2CS35342C10.1039/C2CS35342C ↗
48. 10.1002/adfm.20150301510.1002/adfm.201503015 ↗
49. 10.1002/adma.20120461610.1002/adma.201204616 ↗
50. 10.1016/j.biomaterials.2015.02.05410.1016/j.biomaterials.2015.02.054 ↗
51. 10.1016/j.biomaterials.2016.10.02410.1016/j.biomaterials.2016.10.024 ↗
52. 10.1021/ja906277210.1021/ja9062772 ↗
53. 10.1021/ja508641z10.1021/ja508641z ↗
54. 10.1016/j.biomaterials.2013.03.07710.1016/j.biomaterials.2013.03.077 ↗
55. 10.1016/j.biomaterials.2014.10.07510.1016/j.biomaterials.2014.10.075 ↗
56. 10.1039/c3cs60265f10.1039/c3cs60265f ↗
57. 10.1016/j.biomaterials.2014.12.03710.1016/j.biomaterials.2014.12.037 ↗
58. 10.1039/C3CP43856B10.1039/C3CP43856B ↗
59. 10.1103/PhysRevLett.99.01640610.1103/PhysRevLett.99.016406 ↗
60. 10.1021/cr200358s10.1021/cr200358s ↗
61. 10.1039/C4NR01405G10.1039/C4NR01405G ↗
62. 10.1021/ja107458s10.1021/ja107458s ↗
63. 10.1002/smll.20090207710.1002/smll.200902077 ↗
64. 10.1002/anie.20110450710.1002/anie.201104507 ↗
65. 10.1126/science.107719410.1126/science.1077194 ↗
66. 10.1016/j.jconrel.2011.07.03410.1016/j.jconrel.2011.07.034 ↗
67. 10.1021/jp064341w10.1021/jp064341w ↗
68. 10.1021/acsnano.5b0582510.1021/acsnano.5b05825 ↗
69. 10.1038/nmat157110.1038/nmat1571 ↗
70. 10.1021/acsnano.6b0074510.1021/acsnano.6b00745 ↗
71. 10.1021/acsnano.5b0625910.1021/acsnano.5b06259 ↗
72. 10.1021/nn302782y10.1021/nn302782y ↗
73. 10.1002/anie.20100732110.1002/anie.201007321 ↗
74. 10.1016/j.biomaterials.2009.11.07910.1016/j.biomaterials.2009.11.079 ↗