journal article·2020-03-24

Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing

Yuewei Xi, Juan Ge, Min Wang, Mi Chen, Wen Niu, Wei Cheng, Yumeng Xue, Cai Lin, Bo Lei

ACS Nano· Volume 14· Issue 3
Publisher page

Abstract

Traditional skin tumor surgery and chronic bacterial-infection-induced wound healing/skin regeneration is still a challenge. The ideal strategy should eliminate the tumor, enhance wound healing/skin formation, and be anti-infection. Herein, we designed a multifunctional elastomeric poly(l-lactic acid)-poly(citrate siloxane)-curcumin@polydopamine hybrid nanofibrous scaffold (denoted as PPCP matrix) for tumor-infection therapy and infection-induced wound healing. The PPCP matrix showed intrinsically multifunctional properties including antioxidative, anti-inflammatory, photothermal, antibacterial, anticancer, and angiogenesis bioactivities. The polydopamine/curcumin presented an excellent near-infrared photothermal/cancer cell toxicity capacity, respectively, which supported PPCP for synergetic skin tumor therapy and antibacterial properties in vitro/in vivo. Additionally, the PPCP nanofibrous matrix significantly promotes the adhesion and proliferation of normal skin cells and accelerates the cutaneous wound healing in normal mice and bacterial-infected mice by enhancing the early angiogenesis. The PPCP nanofibrous matrix with multifunctional bioactivities provides a competitive strategy for skin tumor and bacterial-infection-induced wound healing.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Wound Healing and Treatments · Nanoplatforms for cancer theranostics · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000, China

Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China

Department of Bioengineering, Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California at Los Angeles, Los Angeles, California 90095, United States

Department of Burn, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710049, China

Instrumental Analysis Center, Xi’an Jiaotong University, Xi’an 710049, China

Funding

Ministry of Education of the People's Republic of China · National Natural Science Foundation of China · Special Guidance Funds for the Construction of World-class Universities disciplines and Characteristic Development in Central Universities · Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi???an Jiaotong University

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