Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma

Zhilan Chai; Danni Ran; Linwei Lu; Changyou Zhan; Huitong Ruan; Xuefeng Hu; Cao Xie; Kuan Jiang; Jinyang Li; Jianfen Zhou; Jing Wang; Yanyu Zhang; Ronnie H. Fang; Liangfang Zhang; Weiyue Lu

doi:10.1021/acsnano.9b00661

journal article·2019-05-28

Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma

Zhilan Chai, Danni Ran, Linwei Lu, Changyou Zhan, Huitong Ruan, Xuefeng Hu, Cao Xie, Kuan Jiang, Jinyang Li, Jianfen Zhou, Jing Wang, Yanyu Zhang, Ronnie H. Fang, Liangfang Zhang, Weiyue Lu

ACS Nano· Volume 13· Issue 5

Publisher page

Source abstract

Abstract

The safe and efficient delivery of chemotherapeutic agents remains critical to anticancer therapy. Herein, we report on a targeted drug delivery system based upon a modified cell membrane coating technique and drug nanocrystals (NCs). Specifically, red blood cell (RBC) membrane was modified with targeting peptides through a facile insertion method involving avidin-biotin interactions. The RBC membrane-coated drug NCs (RBC-NCs) exhibited high drug loading, long-term stability, excellent biocompatibility, and prolonged retention time, all of which make them suitable for effective drug delivery. When modified with the tumor-targeting peptide c(RGDyK), the resulting RGD-RBC-NCs showed superior tumor accumulation and therapeutic efficacy both in mice bearing a subcutaneous tumor as well as orthotropic glioma. RBC-NC therapeutics can be readily generalized to the delivery of various drugs and for the treatment of a wide range of cancers.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Biomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced biosensing and bioanalysis techniques · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutics, School of Pharmacy and Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Fudan University, Shanghai 201203, China

State Key Laboratory of Medical Neurobiology and the Collaborative Innovation Center for Brain Science and §Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

The Department of Integrative Medicine, Huashan Hospital, Fudan University and The Institutes of Integrative Medicine of Fudan University, Shanghai 200041, China

State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China

Department of Nanoengineering and Moores Cancer Center, University of California San Diego, La Jolla, California 92093, United States

Minhang Branch, Zhongshan Hospital and Institute of Fudan-Minghang Academic Health System, Minghang Hospital, Fudan University, Shanghai 201199, China

Funding

Ministry of Science and Technology of the People's Republic of China · Shanghai Municipal Education Commission · National Natural Science Foundation of China · Shanghai International Science and Technology Cooperation Project

References (47)

Show source-provided references

1. 10.1038/nnano.2007.38710.1038/nnano.2007.387 ↗

2. 10.1038/nrd259110.1038/nrd2591 ↗

3. 10.1038/nrd163210.1038/nrd1632 ↗

4. 10.1038/natrevmats.2016.1410.1038/natrevmats.2016.14 ↗

5. 10.1038/nnano.2013.5410.1038/nnano.2013.54 ↗

6. 10.1002/adma.20150107110.1002/adma.201501071 ↗

7. 10.1039/c3nr03064d10.1039/c3nr03064d ↗

8. 10.1021/nl500618u10.1021/nl500618u ↗

9. 10.1002/adma.20170396910.1002/adma.201703969 ↗

10. 10.1038/nnano.2012.21210.1038/nnano.2012.212 ↗

11. 10.1002/adma.20150332310.1002/adma.201503323 ↗

12. 10.1021/acsnano.5b0213210.1021/acsnano.5b02132 ↗

13. 10.1038/nature1537310.1038/nature15373 ↗

14. 10.1073/pnas.141242011110.1073/pnas.1412420111 ↗

15. 10.1038/s41565-018-0254-410.1038/s41565-018-0254-4 ↗

16. 10.1002/adma.20140015810.1002/adma.201400158 ↗

17. 10.7150/thno.1447110.7150/thno.14471 ↗

18. 10.1021/acsnano.8b0378810.1021/acsnano.8b03788 ↗

19. 10.1088/0957-4484/27/8/08510610.1088/0957-4484/27/8/085106 ↗

20. 10.2217/nnm.12.15310.2217/nnm.12.153 ↗

21. 10.1039/c3nr00015j10.1039/c3nr00015j ↗

22. 10.1002/adfm.20150478010.1002/adfm.201504780 ↗

23. 10.1073/pnas.110663410810.1073/pnas.1106634108 ↗

24. 10.1021/nl504798g10.1021/nl504798g ↗

25. 10.1002/smll.20150098710.1002/smll.201500987 ↗

26. 10.1021/acsami.6b0085310.1021/acsami.6b00853 ↗

27. 10.1088/1361-6528/aa9ca110.1088/1361-6528/aa9ca1 ↗

28. 10.1038/nrd149410.1038/nrd1494 ↗

29. 10.1016/j.jconrel.2018.03.00710.1016/j.jconrel.2018.03.007 ↗

30. 10.1038/nrd436310.1038/nrd4363 ↗

31. 10.1200/JCO.2003.12.04610.1200/JCO.2003.12.046 ↗

32. Chan S. · Oncology · 1997 · 11 · 19

33. 10.1016/j.ejon.2008.10.00310.1016/j.ejon.2008.10.003 ↗

34. 10.1021/bc050113d10.1021/bc050113d ↗

35. 10.1016/j.biomaterials.2013.10.07210.1016/j.biomaterials.2013.10.072 ↗

36. 10.1016/j.jconrel.2012.03.01310.1016/j.jconrel.2012.03.013 ↗

37. 10.1016/j.cell.2018.06.01110.1016/j.cell.2018.06.011 ↗

38. 10.1016/j.jconrel.2013.10.02610.1016/j.jconrel.2013.10.026 ↗

39. 10.1016/j.jconrel.2013.12.01810.1016/j.jconrel.2013.12.018 ↗

40. 10.1002/anie.20141122610.1002/anie.201411226 ↗

41. 10.1016/0003-9861(63)90042-010.1016/0003-9861(63)90042-0 ↗

42. 10.1016/j.jconrel.2015.09.05910.1016/j.jconrel.2015.09.059 ↗

43. 10.1242/jcs.0028110.1242/jcs.00281 ↗

44. 10.1016/j.jconrel.2018.04.03510.1016/j.jconrel.2018.04.035 ↗

45. 10.1002/anie.20110087510.1002/anie.201100875 ↗

46. 10.1016/j.biomaterials.2010.12.02010.1016/j.biomaterials.2010.12.020 ↗

47. 10.1186/1756-9966-32-7510.1186/1756-9966-32-75 ↗