journal article·2015-08-25Open access

Cellphone-Based Hand-Held Microplate Reader for Point-of-Care Testing of Enzyme-Linked Immunosorbent Assays

Brandon Berg, Bingen Cortazar, Derek Tseng, Haydar Ozkan, Steve Feng, Qingshan Wei, Raymond Yan-Lok Chan, Jordi Burbano, Qamar Farooqui, Michael Lewinski, Dino Di Carlo, Omai B. Garner, Aydogan Ozcan

ACS Nano· Volume 9· Issue 8

Abstract

Standard microplate based enzyme-linked immunosorbent assays (ELISA) are widely utilized for various nanomedicine, molecular sensing, and disease screening applications, and this multiwell plate batched analysis dramatically reduces diagnosis costs per patient compared to nonbatched or nonstandard tests. However, their use in resource-limited and field-settings is inhibited by the necessity for relatively large and expensive readout instruments. To mitigate this problem, we created a hand-held and cost-effective cellphone-based colorimetric microplate reader, which uses a 3D-printed opto-mechanical attachment to hold and illuminate a 96-well plate using a light-emitting-diode (LED) array. This LED light is transmitted through each well, and is then collected via 96 individual optical fibers. Captured images of this fiber-bundle are transmitted to our servers through a custom-designed app for processing using a machine learning algorithm, yielding diagnostic results, which are delivered to the user within ∼1 min per 96-well plate, and are visualized using the same app. We successfully tested this mobile platform in a clinical microbiology laboratory using FDA-approved mumps IgG, measles IgG, and herpes simplex virus IgG (HSV-1 and HSV-2) ELISA tests using a total of 567 and 571 patient samples for training and blind testing, respectively, and achieved an accuracy of 99.6%, 98.6%, 99.4%, and 99.4% for mumps, measles, HSV-1, and HSV-2 tests, respectively. This cost-effective and hand-held platform could assist health-care professionals to perform high-throughput disease screening or tracking of vaccination campaigns at the point-of-care, even in resource-poor and field-settings. Also, its intrinsic wireless connectivity can serve epidemiological studies, generating spatiotemporal maps of disease prevalence and immunity.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Biosensors and Analytical Detection · Advanced Biosensing Techniques and Applications · SARS-CoV-2 detection and testing

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Electrical Engineering Department, University of California, Los Angeles, California 90095, United States

Physics and Astronomy Department, University of California, Los Angeles, California 90095, United States

Bioengineering Department, University of California, Los Angeles, California 90095, United States

Biomedical Engineering Department, Fatih Sultan Mehmet Vakif University, Istanbul 34445, Turkey

Roche Molecular Systems, Inc., Pleasanton, California 94588, United States

California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90095, United States

Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California 90095, United States

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States

Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States

Funding

National Science Foundation · Division of Chemical, Bioengineering, Environmental, and Transport Systems · Division of Emerging Frontiers in Research and Innovation · T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu · Howard Hughes Medical Institute

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