DataVXACS NanoPaper
journal article·2012-06-26

Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy

Jian Wang, Guizhi Zhu, Mingxu You, Erqun Song, Mohammed Ibrahim Shukoor, Kejing Zhang, Meghan B. Altman, Yan Chen, Zhi Zhu, Cheng Zhi Huang, Weihong Tan

ACS Nano· Volume 6· Issue 6
Publisher page
Source abstract

Abstract

An aptamer switch probe (ASP) linking chlorin e6 (Ce6), a photosensitizer molecule, to the surface of gold nanorods (AuNRs) was used to target cancer cells for photodynamic therapy (PDT) and photothermal therapy (PTT). In the presence of target cancer cells, the ASP changes conformation to drive Ce6 away from the gold surface, thereby producing singlet oxygen for PDT upon light irradiation. Since each AuNR is modified with many ASP-Ce6 molecules, the AuNR-ASP-Ce6 conjugate yields enhanced binding and therapeutic effect by the added ability to carry many photosensitizers. In addition, absorption of radiation by the gold nanorods enables further cell destruction by the photothermal effect. Consequently, this multimodal AuNR-ASP-Ce6 conjugate offers a remarkably improved and synergistic therapeutic effect compared to PTT or PDT alone, providing high specificity and therapeutic efficiency, which can be generalized to other types of cancer therapies.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Interface of Bio/Nano, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, United States

Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, College of Pharmaceutical Science, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People's Republic of China

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China

References (37)

Show source-provided references
1. Kuo W.-S. · Angew. Chem., Int. Ed. · 2010 · 49 · 271110.1002/anie.200906927 ↗
2. Kah J. C. Y. · Laser Surg. Med. · 2008 · 40 · 58410.1002/lsm.20674 ↗
3. Jang B. · ACS Nano · 2011 · 5 · 108610.1021/nn102722z ↗
4. Barth B. M. · ACS Nano · 2011 · 26 · 532510.1021/nn2005766 ↗
5. Oseroff A. R. · Proc. Natl. Acad. Sci. U. S. A. · 1986 · 83 · 874410.1073/pnas.83.22.8744 ↗
6. Huang Y.-F. · Langmuir · 2008 · 24 · 1186010.1021/la801969c ↗
7. Huang Y.-F. · Anal. Chem. · 2008 · 80 · 56710.1021/ac702322j ↗
8. Koo H. · Acc. Chem. Res. · 2011 · 44 · 101810.1021/ar2000138 ↗
9. Wang H. · ACS Nano · 2009 · 3 · 245110.1021/nn9006303 ↗
10. Kong R.-M. · Small · 2011 · 7 · 242810.1002/smll.201100250 ↗
11. Wang J. · Analyst · 2010 · 135 · 282610.1039/c0an00365d ↗
12. Song S. · Trends Anal. Chem. · 2008 · 27 · 10810.1016/j.trac.2007.12.004 ↗
13. Zhen S. J. · Anal. Chem. · 2010 · 82 · 843210.1021/ac100709s ↗
14. Fang X. · Acc. Chem. Res. · 2010 · 43 · 4810.1021/ar900101s ↗
15. Tang Z. · Anal. Chem. · 2007 · 79 · 490010.1021/ac070189y ↗
16. Sefah K. · Leukemia · 2009 · 23 · 23510.1038/leu.2008.335 ↗
17. Chen X. · J. Biomed. Nanotechnol. · 2008 · 4 · 40010.1166/jbn.2008.002 ↗
18. Tan W. · Trends Biotechnol. · 2011 · 29 · 63410.1016/j.tibtech.2011.06.009 ↗
19. Wang K. · Angew. Chem., Int. Ed. · 2011 · 50 · 609810.1002/anie.201008053 ↗
20. Wu Z. · ACS Nano · 2011 · 5 · 769610.1021/nn2037384 ↗
21. Chang M. · ACS Nano · 2011 · 5 · 615610.1021/nn200693a ↗
22. Kim D. · ACS Nano · 2010 · 4 · 368910.1021/nn901877h ↗
23. Tang Z. · Chem. Asian J. · 2010 · 5 · 78310.1002/asia.200900545 ↗
24. Shieh Y.-A. · ACS Nano · 2010 · 4 · 143310.1021/nn901374b ↗
25. Barth B. M. · ACS Nano · 2011 · 5 · 532510.1021/nn2005766 ↗
26. Chari R. V. J. · Acc. Chem. Res. · 2008 · 41 · 9810.1021/ar700108g ↗
27. Chin W. W. L. · BMC Pharm. · 2007 · 7 · 1510.1186/1471-2210-7-15 ↗
28. Shi H. · Proc. Natl. Acad. Sci. U. S. A. · 2011 · 108 · 390010.1073/pnas.1016197108 ↗
29. Tang Z. · J. Am. Chem. Soc. · 2008 · 130 · 1126810.1021/ja804119s ↗
30. Alkilany A. M. · Adv. Drug Delivery Rev. · 2012 · 64 · 19010.1016/j.addr.2011.03.005 ↗
31. Wang J. · J. Phys. Chem. C · 2008 · 112 · 1169110.1021/jp801993n ↗
32. Huang P. · Biomaterials · 2011 · 32 · 344710.1016/j.biomaterials.2011.01.032 ↗
33. Shangguan D. · Proc. Natl. Acad. Sci. U. S. A. · 2006 · 103 · 1183810.1073/pnas.0602615103 ↗
34. Xiao Z. · Chem.—Eur. J. · 2008 · 14 · 176910.1002/chem.200701330 ↗
35. Zhu Z. · J. Am. Chem. Soc. · 2008 · 130 · 1085610.1021/ja802913f ↗
36. Jang B. · Small · 2010 · 7 · 26510.1002/smll.201001532 ↗
37. Luo Y.-L. · ACS Nano · 2011 · 5 · 779610.1021/nn201592s ↗