Multifunctional Nanoparticles for Combined Doxorubicin and Photothermal Treatments
Source abstract
Abstract
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Extracellular vesicles in disease
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Core Research Center for Nanomedical Technology, Yonsei University, Seoul 120-749, Korea
Department of Physics, Yonsei University, Seoul 120-749, Korea
Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, Korea
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea
Department of Microbiology, Yonsei University, Seoul 120-749, Korea
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