Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators
Source abstract
Abstract
Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. On the bandage, an alternating discrete electric field is generated by a wearable nanogenerator by converting mechanical displacement from skin movements into electricity. Rat studies demonstrated rapid closure of a full-thickness rectangular skin wound within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. From in vitro studies, the accelerated skin wound healing was attributed to electric field-facilitated fibroblast migration, proliferation, and transdifferentiation. This self-powered electric-dressing modality could lead to a facile therapeutic strategy for nonhealing skin wound treatment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Planarian Biology and Electrostimulation · Wound Healing and Treatments · Advanced Sensor and Energy Harvesting Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Science and Engineering, University of Wisconsin—Madison, Madison, Wisconsin 53706, United States
State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, China
Departments of Radiology and Medical Physics, University of Wisconsin—Madison, Madison, Wisconsin 53705, United States
Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430073, China
Department of Surgery, University of Wisconsin—Madison, Madison, Wisconsin 53792, United States
Funding
National Cancer Institute · National Institute of Biomedical Imaging and Bioengineering
References (45)
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