journal article·2014-10-28Open access

Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage

Akhilesh K. Gaharwar, Reginald K. Avery, Alexander Assmann, Arghya Paul, Gareth H. McKinley, Ali Khademhosseini, Bradley D. Olsen

ACS Nano· Volume 8· Issue 10

Abstract

Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve hemostasis, these approaches are difficult to employ on the battlefield and cannot be used for incompressible wounds. Here, we present shear-thinning nanocomposite hydrogels composed of synthetic silicate nanoplatelets and gelatin as injectable hemostatic agents. These materials are demonstrated to decrease in vitro blood clotting times by 77%, and to form stable clot-gel systems. In vivo tests indicated that the nanocomposites are biocompatible and capable of promoting hemostasis in an otherwise lethal liver laceration. The combination of injectability, rapid mechanical recovery, physiological stability, and the ability to promote coagulation result in a hemostat for treating incompressible wounds in out-of-hospital, emergency conditions.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Hemostasis and retained surgical items · Surgical Sutures and Adhesives · Trauma, Hemostasis, Coagulopathy, Resuscitation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, United States

Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, United States

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Department of Cardiovascular Surgery, Heinrich Heine University, Medical Faculty, 40225 Duesseldorf, Germany

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Funding

Fonds de Recherche du Québec - Santé · Army Research Office

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