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journal article·2011-11-22Open access

NIR-to-NIR Two-Photon Excited CaF2:Tm3+,Yb3+ Nanoparticles: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging

Ning-Ning Dong, Marco Pedroni, Fabio Piccinelli, Giamaica Conti, Andrea Sbarbati, Juan Enrique Ramírez-Hernández, Laura Martínez Maestro, Maria Carmen Iglesias-de la Cruz, Francisco Sanz-Rodriguez, Angeles Juarranz, Feng Chen, Fiorenzo Vetrone, John A. Capobianco, José García Solé, Marco Bettinelli, Daniel Jaque, Adolfo Speghini

ACS Nano· Volume 5· Issue 11
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Source abstract

Abstract

In this study, we report on the remarkable two-photon excited fluorescence efficiency in the "biological window" of CaF(2):Tm(3+),Yb(3+) nanoparticles. On the basis of the strong Tm(3+) ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF(2):Er(3+),Yb(3+) nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF(2):Tm(3+),Yb(3+) nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Luminescence Properties of Advanced Materials · Nanoplatforms for cancer theranostics · Quantum Dots Synthesis And Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain

School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China

Dipartimento di Biotecnologie, Università di Verona and INSTM, UdR Verona, Ca’Vignal, Strada Le Grazie 15, 37134 Verona, Italy

Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Università di Verona, Piazzale L.A. Scuro, 10-37134 Verona, Italy

Departamento de Investigación en Física, Universidad de Sonora, Hermosillo 5-88, 83190 México

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, C/Arzobispo Morcillo s/n 29029 Madrid, Spain

Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain

Institut National de la Recherche Scientifique-Énergie, Matériaux et Télécommunications, Université du Québec, Varennes, QC J3X 1S2, Canada

Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada

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