journal article·2016-01-26Open access

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Xiang Wu, Yuanwei Zhang, Kendra Takle, Osman Bilsel, Zhanjun Li, Hyungseok Lee, Zijiao Zhang, Dongsheng Li, Wei Fan, Chunying Duan, Emory M. Chan, Carlos Lois, Yang Xiang, Gang Han

ACS Nano· Volume 10· Issue 1

Abstract

Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb(3+)) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Photoreceptor and optogenetics research · bioluminescence and chemiluminescence research · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, People’s Republic of China

Department of Materials Science & Engineering, Zhejiang University, Hangzhou, 310027, People’s Republic of China

Materials Sciences, Physical and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, United States

Chemical Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003, United States

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States

Funding

Basic Energy Sciences · Human Frontier Science Program · U.S. Department of Energy · China Scholarship Council · National Institute of Mental Health · Worcester Foundation for Biomedical Research

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