journal article·2021-03-23

High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy

Xiangqin Meng, Dandan Li, Lei Chen, Helen He, Qian Wang, Chaoyi Hong, Jiuyang He, Xingfa Gao, Yili Yang, Bing Jiang, Guohui Nie, Xiyun Yan, Lizeng Gao, Kelong Fan

ACS Nano· Volume 15· Issue 3
Publisher page

Abstract

OH and deplete reduced glutathione, which induces apoptosis as well as ferroptosis of tumor cells. Consequently, it killed apoptosis-resistant tumor cells harboring KRAS mutation by inducing ferroptosis. The pyrite nanozyme also exhibited favorable tumor-specific cytotoxicity and biodegradability to ensure its biosafety. These results indicate that the high-performance pyrite nanozyme is an effective therapeutic reagent and may aid the development of nanozyme-based tumor catalytic therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

School of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China

Department of Pharmacology, School of Medicine, Institute of Translational Medicine, Yangzhou University, Yangzhou 225001, Jiangsu, China

School of Life Sciences, Tsinghua University, Beijing 100084, China

Laboratory of Theoretical and Computational Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China

Suzhou Institute of Systems Medicine, Center for Systems Medicine, Chinese Academy of Medicine Sciences, Suzhou 215123, Jiangsu, China

Nanozyme Medical Center, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, Henan, China

Department of Otolaryngology and Institute of Translational Medicine, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, Guangdong, China

Funding

Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Jiangsu Province · Youth Innovation Promotion Association of the Chinese Academy of Sciences · National Natural Science Foundation of China · Chinese Academy of Sciences · CAS Interdisciplinary Innovation Team · Sanming Project of Medicine in Shenzhen

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