journal article·2017-12-26

A Decade of the Protein Corona

Pu Chun Ke, Sijie Lin, Wolfgang J. Parak, Thomas P. Davis, Frank Caruso

ACS Nano· Volume 11· Issue 12
Publisher page

Abstract

In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio-nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle-protein entity in in vitro and in vivo environments, the role of stealth polymers to minimize the formation of the protein corona, relevant computational and theoretical developments, and the "biocorona", a concept extrapolated from the field of nanomedicine. We conclude the Perspective by outlining future directions and opportunities concerning the protein corona in the coming decade.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Polymer Surface Interaction Studies · Iron oxide chemistry and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, 1239 Siping Road, Shanghai 200092, China

Fachbereich Physik und Chemie and CHyN, University of Hamburg, 22607 Hamburg, Germany

Department of Chemistry, University of Warwick, Gibbet Hill, Coventry CV4 7AL, United Kingdom

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia

Funding

Deutsche Forschungsgemeinschaft · Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology

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