Physical Principles of Nanoparticle Cellular Endocytosis
Source abstract
Abstract
This review article focuses on the physiochemical mechanisms underlying nanoparticle uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between the nanoparticles and the cell membrane generate forces from different origins. This leads to the membrane wrapping of the nanoparticles followed by cellular uptake. This article discusses how the kinetics, energetics, and forces are related to these interactions and dependent on the size, shape, and stiffness of nanoparticles, the biomechanical properties of the cell membrane, as well as the local environment of the cells. The discussed fundamental principles of the physiochemical causes for nanoparticle-cell interaction may guide new studies of nanoparticle endocytosis and lead to better strategies to design nanoparticle-based approaches for biomedical applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Force Microscopy Techniques and Applications · Lipid Membrane Structure and Behavior
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
School of Engineering, Brown University, Providence, Rhode Island 02912, United States
Department of Bioengineering, Rice University, Houston, Texas 77005, United States
Funding
Division of Civil, Mechanical and Manufacturing Innovation · Division of Chemical, Bioengineering, Environmental, and Transport Systems · National Heart, Lung, and Blood Institute · National Eye Institute
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