DataVXACS Materials LettersPaper
journal article·2025-12-01

Homooligomeric Nanostructure Transition from RNAs to DNAs

Hongfei He, Simeng Ji, Xiaoqiu Zheng, Yilin Wang, Yuanqin Luo, Yan Zhou, Tingyu Zhu, Yuchuan Zhou, Meiling Fei, Ting Zhao, Qiuyu Liao, Huan Xu, Lin Xiao, Jiazhen Lyu

ACS Materials Letters· Volume 7· Issue 12
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Source abstract

Abstract

RNAs and DNAs with identical sequences often adopt distinct structures. To understand the connection between RNA and DNA structures of an identical sequence, we used the RNA square as an experimental model to study the structural transformation from RNAs to DNAs. Interestingly, we found that the RNA square can transform into a mixture of square and triangle by gradually replacing RNA with DNA nucleotides and finally transform into a DNA triangle by total DNA nucleotide replacement. The oxDNA simulation results reveal that the RNA–DNA hybrid square becomes destabilized, while a hybrid triangle emerges. Further, by reducing the loop length of the DNA motif, it could assemble into triangles, squares, or pentagons with sufficient flexibility, similar to the RNA ones. Our experimental results have demonstrated the different self-assembly pathways of RNA and DNA with the same sequence, which provides a homoassembly strategy for studying the structural transformation from RNAs to DNAs.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: DNA and Nucleic Acid Chemistry · Advanced biosensing and bioanalysis techniques · Origins and Evolution of Life

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College; School of Laboratory Medicine & Translational Medicine Research Center

North Sichuan Medical College

Department of Clinical Laboratory Medicine

The General Hospital of Xizang Military Command

School of Pharmacy & School of Stomatology

Department of Oncology

Affiliated Hospital of North Sichuan Medical College

Funding

National Natural Science Foundation of China · Sichuan Health Commission · Sichuan Students' Platform for innovation training program · Research and Development Fund Project of North Sichuan Medical College · Project of Sichuan Provincial Administration of Traditional Chinese Medicine · Sichuan Science and Technology Program

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