journal article·2023-09-04

Engineering Seed-like Fe–Mn Nanomedicine with Ultrasmall Structure and ATP-Responsive Function for Tumor Metabolic and Redox Subversion

Junlie Yao, Zihou Li, Zhouhua Li, Xiaoxia Wu, Chunshu Pan, Jie Xing, Aoran Zhang, Bo Jiang, Fang Yang, Aiguo Wu

ACS Materials Letters· Volume 5· Issue 9
Publisher page

Abstract

Since adenosine triphosphate (ATP) is an indispensable substance for tumor survival, intracellular ATP regulation has emerged as a cutting-edge antineoplastic strategy. Nevertheless, most ATP-responsive anticancer nanomedicines are established with DNA structure, coordinate polymer, and glucose oxidase as the core. Herein, in order to excavate the design possibilities of ATP-responsive nanoplatforms, an ultrasmall iron (Fe)-manganese (Mn) nanomedicine (<5 nm) was designed by a combination of bottom-up and top-down approaches, employing Fe-based reductant and Mn-based oxidant as raw materials. Due to the polyvalent Fe/Mn states, as-prepared nanomedicine was featured with ATP, hydrogen peroxide (H 2 O 2 ), and nicotinamide adenine dinucleotide phosphate (NADPH) reactivities to disrupt the metabolic and redox homeostasis of breast cancer and bone metastases sites. In addition, this nanomedicine was well-suited to offer dual-mode T 1 /T 2 magnetic resonance imaging (MRI) for tumor detection. Therefore, this work provides a novel attempt for the exploitation of ultrasmall ATP-responsive antineoplastic nanomedicine.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Cixi Institute of Biomedical Engineering, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P.R. China

University of Chinese Academy of Sciences, Beijing 100049, P.R. China

Department of Radiology, Ningbo No. 2 Hospital, Ningbo 315000, P.R. China

Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, P.R. China

Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo 315201, P.R. China

Funding

Ningbo Municipal Bureau of Science and Technology · Science and Technology Department of Zhejiang Province · Youth Innovation Promotion Association of the Chinese Academy of Sciences · National Natural Science Foundation of China · 3315 Innovation Team in Ningbo City · Ningbo Leading Medical and Health Discipline

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